Ohnishi K, Nakayama T, Saito M, Hatano H, Nomura F, Iida S, Okuda K
Am J Gastroenterol. 1985 Apr;80(4):290-3.
Effects of two histamine H2 receptor antagonists, cimetidine and ranitidine, on systemic and splanchnic hemodynamics were studied in patients with chronic liver disease by simultaneous catheterization of the portal vein and the right hepatic vein and measurement of portal venous flow using the ultrasound doppler system or cineangiography. Neither infusion of 200 mg of cimetidine nor 50 mg of ranitidine reduced cardiac output, portal venous pressure, the gradient between wedged hepatic venous pressure and free hepatic venous pressure, hepatic blood flow, and portal venous flow. It is unlikely that histamine is an important modulator of flow via the H2 receptor.
通过同时对门静脉和右肝静脉进行插管，并使用超声多普勒系统或血管造影术测量门静脉血流，研究了两种组胺H2受体拮抗剂西咪替丁和雷尼替丁对慢性肝病患者全身和内脏血流动力学的影响。静脉输注200mg西咪替丁或50mg雷尼替丁均未降低心输出量、门静脉压力、肝静脉楔压与游离肝静脉压力之间的梯度、肝血流量和门静脉血流。组胺不太可能是通过H2受体调节血流的重要调节因子。
