Cole M J, Shapero T F, Saibil E A
Can Med Assoc J. 1983 Jan 15;128(2):131-2.
Portal pressure was determined in 10 patients with chronic liver disease before and after an infusion of cimetidine. The drug had no significant effect on portal hypertension. Suggestions that histamine H2-receptor antagonists, by decreasing portal pressure, may be useful in the management of bleeding from esophageal varices are not supported by these results.
在10例慢性肝病患者中,于静脉输注西咪替丁前后测定门静脉压力。该药物对门静脉高压无显著影响。组胺H2受体拮抗剂通过降低门静脉压力可能有助于治疗食管静脉曲张出血的观点未得到这些结果的支持。