Dandurand K R, Stennett D J
Am J Hosp Pharm. 1985 Mar;42(3):595-7.
The stability of dopamine hydrochloride in 5% dextrose injection when exposed to blue-light phototherapy was assessed. Solutions of dopamine hydrochloride (1000 micrograms/mL) were prepared, and samples were subjected to one of three light sources (fluorescent, dark, phototherapy) and two flow rates (2 mL/hr and no flow) at ambient room temperature. Irradiation levels were maintained between 5.1 and 6.6 microwatts/sq cm throughout the experiment. Samples obtained at 0 to 36 hours were assayed using high-performance liquid chromatography. There were no significant differences in dopamine stability among the sample groups exposed to the various light and flow conditions over the 36-hour study period. Dopamine hydrochloride in 5% dextrose injection exposed to phototherapy is stable for 36 hours at 1000 micrograms/mL. It is not necessary to protect dopamine solutions from blue-light irradiance to ensure clinically acceptable stability.
评估了盐酸多巴胺在5%葡萄糖注射液中暴露于蓝光光疗时的稳定性。制备了盐酸多巴胺溶液（1000微克/毫升），在室温环境下，样品分别置于三种光源（荧光、黑暗、光疗）之一和两种流速（2毫升/小时和无流速）条件下。在整个实验过程中，辐照水平维持在5.1至6.6微瓦/平方厘米之间。在0至36小时获取的样品使用高效液相色谱法进行测定。在36小时的研究期间，暴露于各种光照和流速条件下的样品组之间，多巴胺稳定性没有显著差异。暴露于光疗的5%葡萄糖注射液中的盐酸多巴胺在1000微克/毫升浓度下36小时内是稳定的。为确保临床上可接受的稳定性，无需对多巴胺溶液进行蓝光辐照防护。
