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在预培养液中使用芦丁和槲皮素或通过口服给药提高体外受精的受精率。

Improving fertilization rates in IVF using rutin and quercetin in preculture medium or through oral administration.

作者信息

Tanaka Hiromitsu, Ichihara Satona

机构信息

Faculty of Pharmaceutical Sciences, Nagasaki International University, Sasebo, Nagasaki, Japan.

出版信息

Front Vet Sci. 2025 Jan 9;11:1506029. doi: 10.3389/fvets.2024.1506029. eCollection 2024.

DOI:10.3389/fvets.2024.1506029
PMID:39850587
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11756508/
Abstract

Fertility rates are declining in livestock such as cattle, and more than one in five Japanese couples have undergone infertility treatment or are currently infertile. Improving the fertilization rates of domesticated animals is imperative for improving their productivity and maintaining valuable lineages. In this study, the effects of rutin and quercetin on fertility and pregnancy rates were investigated by incorporating these compounds into the preculture medium for fertilization (IVF) or administering them orally to mice. The addition of rutin and quercetin to the preculture medium increased the IVF fertilization rate by more than twofold. Oral administration of rutin and quercetin to aged male and nulliparous female mice improved pregnancy outcomes. These findings have important implications for the non-invasive treatment of infertility.

摘要

牛等家畜的生育率正在下降，超过五分之一的日本夫妇接受过不孕治疗或目前患有不孕症。提高家畜的受精率对于提高其生产力和维持珍贵的血统至关重要。在本研究中，通过将芦丁和槲皮素添加到体外受精（IVF）的预培养基中或对小鼠口服给药，研究了它们对生育率和妊娠率的影响。在预培养基中添加芦丁和槲皮素可使IVF受精率提高两倍以上。对老年雄性和未生育雌性小鼠口服芦丁和槲皮素可改善妊娠结局。这些发现对不孕症的非侵入性治疗具有重要意义。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d4d0/11756508/c60118f585e1/fvets-11-1506029-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d4d0/11756508/53d2d39792ea/fvets-11-1506029-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d4d0/11756508/a4805b534749/fvets-11-1506029-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d4d0/11756508/3ae80e299d70/fvets-11-1506029-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d4d0/11756508/c60118f585e1/fvets-11-1506029-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d4d0/11756508/53d2d39792ea/fvets-11-1506029-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d4d0/11756508/a4805b534749/fvets-11-1506029-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d4d0/11756508/3ae80e299d70/fvets-11-1506029-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d4d0/11756508/c60118f585e1/fvets-11-1506029-g004.jpg

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Investigating the Suitability of Mare's Milk-Derived Exosomes as Potential Drug Carriers.探究马乳来源的外泌体作为潜在药物载体的适用性。
Biomolecules. 2024 Oct 1;14(10):1247. doi: 10.3390/biom14101247.
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Untargeted Metabolomic Profiling of Extracellular Vesicles Isolated from Human Seminal Plasma.
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Quercetin, the Potential Powerful Flavonoid for Human and Food: A Review.槲皮素，人类和食品的潜在强力类黄酮：综述。
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Nighttime Blood Pressure Abnormalities in Iranian CKD Patients: Necessity to Perform Ambulatory Blood Pressure Monitoring.伊朗慢性肾脏病患者夜间血压异常：有必要进行动态血压监测。
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Sci Rep. 2024 Jan 2;14(1):287. doi: 10.1038/s41598-023-50712-1.
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