Tanaka Hiromitsu, Matsushita Hiroaki, Tokuhiro Keizo, Fukunari Atsushi, Ando Yukio
Faculty of Pharmaceutical Sciences, Nagasaki International University, 2825-7 Huis Ten Bosch, Sasebo 859-3298, Japan.
Department of Genome Editing, Institute of Biomedical Science, Kansai Medical University, Hirakata City 573-1191, Japan.
Biology (Basel). 2023 Feb 16;12(2):320. doi: 10.3390/biology12020320.
The MATP/tau protein is hyperphosphorylated in Alzheimer's patients. Therefore, research into the regulation of tau protein phosphorylation is important for understanding Alzheimer's disease. HASPIN is a serine/threonine kinase that is expressed in various cells. To examine whether HASPIN is involved in the onset of Alzheimer's disease through tau protein phosphorylation, we investigated the effects of a diet including soybean sprouts rich in the HASPIN inhibitor coumestrol in a mouse model of Alzheimer's disease (5xFAD). The results showed that HASPIN was expressed in the hippocampus and phosphorylated tau protein, while the ingestion of soybean sprouts containing coumestrol suppressed the development of spatial cognitive dysfunction in 5xFAD. These results indicate that HASPIN may be one of the target molecules for the repression of tau phosphorylation in the treatment of Alzheimer's disease.
在阿尔茨海默病患者中，MATP/tau蛋白存在过度磷酸化。因此，研究tau蛋白磷酸化的调控对于理解阿尔茨海默病很重要。HASPIN是一种在各种细胞中表达的丝氨酸/苏氨酸激酶。为了研究HASPIN是否通过tau蛋白磷酸化参与阿尔茨海默病的发病过程，我们在阿尔茨海默病小鼠模型（5xFAD）中研究了含有富含HASPIN抑制剂香豆雌酚的豆芽的饮食的影响。结果表明，HASPIN在海马体中表达且使tau蛋白磷酸化，而摄入含有香豆雌酚的豆芽可抑制5xFAD小鼠空间认知功能障碍的发展。这些结果表明，HASPIN可能是治疗阿尔茨海默病时抑制tau磷酸化的靶分子之一。
