Sandvold Olivia F, Ge Yinglin, Proksa Roland, Noël Peter B
Department of Radiology, Perelman School of Medicine, Philadelphia, PA USA.
Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA.
Conf Proc Int Conf Image Form Xray Comput Tomogr. 2024 Aug;2024:268-271.
Despite the evident benefits of spectral computed tomography (CT) in delivering qualitative imaging superior to that of conventional CT in adults, its application in pediatric diagnostic imaging is still relatively limited due to various reasons, including design limitations and radiation dose considerations. The use of specialized K-edge filters, in conjunction with other spectral technologies, has been demonstrated to improve spectral quantification accuracy. X-ray flux limitations generally pose challenges in these concepts when applied to adults. However, such limitations are not present in pediatric imaging, allowing the full exploitation of K-edge filters to improve performance. To facilitate the adoption of spectral CT's benefits, as seen in the adult population, into pediatric settings, we introduce an innovative double bowtie filter design. This design incorporates a K-edge material coupled with Teflon and is integrated with rapid kVp-switching technology. A Python simulation was built to model a rapid kVp-switching x-ray tube and to estimate Cramer-Rao lower bound (CRLB) noise in photoelectric and Compton scatter basis domains. We estimate a conventional bowtie filter and corresponding reference patient dose before optimizing double bowtie configurations to contain the highest obtainable spectral signal-to-noise content for the specified phantom. Our findings indicate that an optimal combination of holmium and Teflon in the filter geometry can increase spectral SNR up to twofold the conventional estimates, while still maintaining low radiation dose exposure. This study broadens the scope for pediatric patients to fully benefit from the capabilities of spectral CT.
尽管光谱计算机断层扫描(CT)在提供优于成人传统CT的定性成像方面具有明显优势,但由于各种原因,包括设计限制和辐射剂量考虑,其在儿科诊断成像中的应用仍然相对有限。事实证明,使用专门的K边滤波器并结合其他光谱技术,可以提高光谱定量的准确性。当应用于成人时,X射线通量限制通常会给这些概念带来挑战。然而,儿科成像中不存在此类限制,这使得可以充分利用K边滤波器来提高性能。为了便于将成人中所见的光谱CT的优势应用于儿科环境,我们引入了一种创新的双蝴蝶结滤波器设计。这种设计将一种K边材料与特氟龙相结合,并与快速千伏切换技术集成在一起。构建了一个Python模拟,以对快速千伏切换X射线管进行建模,并估计光电和康普顿散射基域中的克拉美-罗下界(CRLB)噪声。在优化双蝴蝶结配置以包含指定体模可获得的最高光谱信噪比之前,我们估计了传统蝴蝶结滤波器和相应的参考患者剂量。我们的研究结果表明,滤波器几何结构中钬和特氟龙的最佳组合可以使光谱信噪比提高到传统估计值的两倍,同时仍保持低辐射剂量暴露。这项研究拓宽了儿科患者充分受益于光谱CT功能的范围。