Liu Mingyu, Teng Teng
Key Laboratory of Tropical Translational Medicine and Ministry of Education, Hainan Academy of Medical Sciences, Hainan Medical University, Haikou, China.
School of Stomatology, Hainan Academy of Medical Sciences, Hainan Medical University, Haikou, China.
Front Cell Dev Biol. 2025 Jan 9;12:1510862. doi: 10.3389/fcell.2024.1510862. eCollection 2024.
Axon guidance is a key event in neural circuit development that drives the correct targeting of axons to their targets through long distances and unique patterns. Exosomes, extracellular vesicles that are smaller than 100 nm, are secreted by most cell types in the brain. Regulation of cell-cell communication, neuroregeneration, and synapse formation by exosomes have been extensively studied. However, the interaction between exosomes and axon guidance molecules is poorly understood. This review summarizes the relationship between exosomes and canonical and non-canonical guidance cues and hypothesizes a possible model for exosomes mediating axon guidance between cells. The roles of exosomes in axon outgrowth, regeneration, and neurodevelopmental disorders are also reviewed, to discuss exosome-guidance interactions as potential clinical therapeutic targets.
轴突导向是神经回路发育中的关键事件，它驱动轴突通过长距离和独特模式正确靶向其目标。外泌体是小于100纳米的细胞外囊泡，由大脑中的大多数细胞类型分泌。外泌体对细胞间通讯、神经再生和突触形成的调节已得到广泛研究。然而，外泌体与轴突导向分子之间的相互作用却知之甚少。本综述总结了外泌体与经典和非经典导向线索之间的关系，并提出了一个外泌体介导细胞间轴突导向的可能模型。还对外泌体在轴突生长、再生和神经发育障碍中的作用进行了综述，以探讨外泌体导向相互作用作为潜在临床治疗靶点的可能性。
