硫化氢与肾脏：在肾脏生理学、肾脏损伤及疾病的发病机制和治疗中发挥重要作用
Hydrogen sulphide and the kidney: important roles in renal physiology and pathogenesis and treatment of kidney injury and disease.
作者信息
Lobb I, Sonke E, Aboalsamh G, Sener A
机构信息
Department of Microbiology and Immunology, Western University, London, Ontario, Canada; Matthew Mailing Center for Translational Transplant Studies, London Health Sciences Center, Western University, London, Ontario, Canada.
Matthew Mailing Center for Translational Transplant Studies, London Health Sciences Center, Western University, London, Ontario, Canada; Department of Anatomy and Cell Biology, Western University, London, Ontario, Canada.
出版信息
Nitric Oxide. 2015 Apr 30;46:55-65. doi: 10.1016/j.niox.2014.10.004. Epub 2014 Oct 24.
The kidney is an essential mammalian organ that serves to filter toxins and metabolic by-products out of the blood, which are then excreted through urine. Hydrogen sulphide (H2S) is a recently characterized, endogenous gaseous molecule with important physiological roles. Many interesting roles continue to be identified for H2S related specifically to the kidney. The current review discusses how production and action of H2S influences normal physiology of the kidney. We investigate as well the many roles H2S plays in the pathogenesis and treatment of kidney injury and disease, such as chronic kidney disease (CKD), ureteral obstruction (UO), hyperhomocysteinaemia (HHcy), drug-induced nephrotoxicity (DIN) and renal ischaemia reperfusion injury (IRI). We suggest that H2S plays a complex and essential role in the normal function of the kidney and dysregulation of H2S production can directly or indirectly contribute to the pathogenesis of renal disease and injury. Also, H2S could be a promising potential therapeutic treatment to decrease the severity of several renal diseases. Further research will identify increasingly important and complex roles for H2S in renal physiology and how H2S can be effectively utilized to improve clinical outcomes of renal disease.
肾脏是哺乳动物的重要器官，其作用是从血液中过滤毒素和代谢副产物，然后通过尿液排出。硫化氢（H₂S）是一种最近被鉴定出来的具有重要生理作用的内源性气体分子。目前已发现许多与肾脏特异性相关的H₂S的有趣作用。本综述讨论了H₂S的产生和作用如何影响肾脏的正常生理功能。我们还研究了H₂S在肾脏损伤和疾病（如慢性肾脏病（CKD）、输尿管梗阻（UO）、高同型半胱氨酸血症（HHcy）、药物性肾毒性（DIN）和肾缺血再灌注损伤（IRI））的发病机制和治疗中的多种作用。我们认为，H₂S在肾脏的正常功能中发挥着复杂而重要的作用，H₂S产生的失调可直接或间接导致肾脏疾病和损伤的发病机制。此外，H₂S可能是一种有前景的潜在治疗方法，可减轻几种肾脏疾病的严重程度。进一步的研究将确定H₂S在肾脏生理学中越来越重要和复杂的作用，以及如何有效利用H₂S来改善肾脏疾病的临床结果。
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