Grzonkowska Magdalena, Bogacz Katarzyna, Żytkowski Andrzej, Szkultecka-Dębek Monika, Kułakowski Michał, Janiak Michał, Rogalska Agnieszka, Baumgart Mariusz
Department of Normal Anatomy, The Ludwik Rydygier Collegium Medicum in Bydgoszcz, The Nicolaus Copernicus University in Toruń, 87-100 Toruń, Poland.
Physiotherapy Department, Faculty of Physical Education and Physiotherapy, Opole University of Technology, 45-758 Opole, Poland.
Brain Sci. 2025 Jan 15;15(1):74. doi: 10.3390/brainsci15010074.
The aim of the present study was to examine the growth dynamics of the first sacral vertebra and its ossification center in the human fetus, based on their linear, planar, and volumetric parameters.
The examinations were carried out on 54 human fetuses of both sexes (26 males and 28 females) aged 18-30 weeks of gestation, which had been preserved in 10% neutral formalin solution. Using CT, digital image analysis software, 3D reconstruction, and statistical methods, the size of the first sacral vertebra and its ossification center was evaluated.
The first sacral vertebra and its ossification center grew proportionately according to fetal weeks.
The numerical data obtained from computed tomography and the growth patterns of the body of the first sacral vertebra and its ossification center may serve as age-specific normative intervals relevant for gynecologists, obstetricians, pediatricians, and radiologists during fetal ultrasound screening. Our findings on the growth of the body of the first sacral vertebra and its ossification center may be useful in daily clinical practice, particularly in ultrasonic monitoring of normal fetal growth and in screening for congenital defects and skeletal dysplasias.
本研究旨在基于线性、平面和体积参数，研究人类胎儿第一骶椎及其骨化中心的生长动态。
对54例孕龄18 - 30周的男女胎儿（男26例，女28例）进行检查，这些胎儿保存在10%中性福尔马林溶液中。使用CT、数字图像分析软件、三维重建和统计方法，评估第一骶椎及其骨化中心的大小。
第一骶椎及其骨化中心随孕周成比例生长。
从计算机断层扫描获得的数值数据以及第一骶椎椎体及其骨化中心的生长模式，可作为胎儿超声筛查期间妇科医生、产科医生、儿科医生和放射科医生的特定年龄标准区间。我们关于第一骶椎椎体及其骨化中心生长的研究结果可能在日常临床实践中有用，特别是在正常胎儿生长的超声监测以及先天性缺陷和骨骼发育异常的筛查中。
