Gelsema A J, Bouman L N, Karemaker J M
Am J Physiol. 1985 Apr;248(4 Pt 2):R426-33. doi: 10.1152/ajpregu.1985.248.4.R426.
The short-latency effect on heart rate of peripheral nerve stimulation was studied in decerebrate cats. Selective activation (17-40 microA, 100 Hz, 1 s long) of low-threshold fibers in the nerves to the triceps surae muscle yielded isometric contractions of maximal force that were accompanied by a cardiac cycle length shortening within 0.4 s from the start of stimulation. This effect was abolished by pharmacologically induced neuromuscular blockade. The cardiac cycle length shortening during paralysis reappeared after a 6- to 10-fold increase of the stimulation strength. Cutaneous (sural) nerve stimulation (15-25 microA, 100 Hz, 1 s long) elicited reflex contractions in the stimulated limb, which were also accompanied by a cardiac acceleration with similar latency. Paralysis prevented the reflex contractions and reduced the cardiac response in some cats and abolished it in others. The response reappeared in either case after a 5- to 10-fold increase of the stimulus strength. It is concluded that muscle nerve and cutaneous nerve activity both cause a similar cardiac acceleration with a latency of less than 0.4 s. The response to muscle nerve stimulation is elicited by activity in group III afferents. It is excluded that the cardiac response to nerve stimulation is secondary to a change in the respiratory pattern.
在去大脑猫中研究了外周神经刺激对心率的短潜伏期效应。选择性激活（17 - 40微安，100赫兹，持续1秒）腓肠肌神经中的低阈值纤维会产生最大力量的等长收缩，同时从刺激开始0.4秒内伴随心动周期长度缩短。这种效应可通过药物诱导的神经肌肉阻滞消除。麻痹期间心动周期长度缩短在刺激强度增加6至10倍后再次出现。皮肤（腓肠）神经刺激（15 - 25微安，100赫兹，持续1秒）在受刺激肢体引发反射性收缩，同时也伴有类似潜伏期的心率加速。麻痹可防止反射性收缩，在一些猫中会降低心脏反应，在另一些猫中则会消除心脏反应。在两种情况下，刺激强度增加5至10倍后反应都会再次出现。得出的结论是，肌肉神经和皮肤神经活动都会引起类似的心率加速，潜伏期小于0.4秒。对肌肉神经刺激的反应是由Ⅲ类传入神经的活动引发的。排除了对神经刺激的心脏反应是呼吸模式改变的继发结果。
