Gelsema A J, De Groot G, Bouman L N
J Appl Physiol Respir Environ Exerc Physiol. 1983 Sep;55(3):703-10. doi: 10.1152/jappl.1983.55.3.703.
The short-latency effect of peripheral nerve stimulation on heart rate was studied in decerebrate cats. Stimulus trains (100 Hz) of 1-s duration were given to the tibial nerve or to muscle nerves with an intensity yielding a maximal force of isometric contraction of the triceps surae muscle. The first detectable sign and the maximum of cardiac cycle length shortening were found at 0.5-0.6 and 2.1 +/- 0.4 (SD) s, respectively, after the onset of stimulation. A positive correlation exists between the basic cycle length (i.e., before nerve stimulation) and the stimulation-induced shortening of cycle length. The average maximum shortening was found to be 6.7% of basic cycle length. Atropine (0.05-0.1 mg/kg) or bilateral vagotomy suppresses the heart rate response almost completely, whereas the administration of propranolol (2 mg/kg) leaves the response intact. When the nerve is cut proximal to the site of stimulation, the response disappears. Paralysis of the muscle diminishes the response upon nerve stimulation. It is concluded that the short-latency response studied here can be considered as a muscle-heart reflex that is similar to the one previously found in humans.
在去大脑猫中研究了外周神经刺激对心率的短潜伏期效应。以产生比目鱼肌等长收缩最大力量的强度，对胫神经或肌肉神经给予持续1秒的刺激串（100Hz）。在刺激开始后，分别在0.5 - 0.6秒和2.1±0.4（标准差）秒时发现了心动周期长度缩短的第一个可检测迹象和最大值。基础周期长度（即神经刺激前）与刺激引起的周期长度缩短之间存在正相关。平均最大缩短量为基础周期长度的6.7%。阿托品（0.05 - 0.1mg/kg）或双侧迷走神经切断术几乎完全抑制心率反应，而给予普萘洛尔（2mg/kg）则使反应保持不变。当在刺激部位近端切断神经时，反应消失。肌肉麻痹会减弱神经刺激后的反应。结论是，这里研究的短潜伏期反应可被视为一种肌肉 - 心脏反射，类似于先前在人类中发现的反射。
