Lasorsa Francesco, Biasatti Arianna, Orsini Angelo, Bignante Gabriele, Farah Gabriana M, Pandolfo Savio Domenico, Lambertini Luca, Reddy Deepika, Damiano Rocco, Ditonno Pasquale, Lucarelli Giuseppe, Autorino Riccardo, Vourganti Srinivas
Department of Urology, Rush University, Chicago, IL 60612, USA.
Department of Precision and Regenerative Medicine and Ionian Area-Urology, Andrology and Kidney Transplantation Unit, University of Bari "Aldo Moro", 70121 Bari, Italy.
Curr Oncol. 2024 Dec 28;32(1):15. doi: 10.3390/curroncol32010015.
Focal therapy has emerged as a balanced middle ground aiming to reduce overtreatment and the risk of progression, as well as patients' distress and anxiety. Focal therapy and partial gland ablation prioritize the precise elimination of the index lesion and a surrounding safety margin to optimize treatment outcomes and lower the risk of residual disease. The paradigm of whole-gland ablation has shifted towards more targeted approaches. Several treatment templates ranging from subtotal and hemiablation to "hockey-stick", quadrant, and even focal lesion ablation have emerged. Many types of energy may be utilized during focal treatment. First, focal therapy can be grossly classified into thermal vs. non-thermal energy. The aim of this non-systematic review is to offer a comprehensive analysis of recently available evidence on focal therapy for PCa.
聚焦治疗已成为一种平衡的中间立场，旨在减少过度治疗、疾病进展风险以及患者的痛苦和焦虑。聚焦治疗和部分腺体消融优先精确消除索引病灶及周围安全 margins，以优化治疗效果并降低残留疾病风险。全腺体消融模式已转向更具针对性的方法。出现了几种治疗模板，从次全消融和半消融到“曲棍球棒”、象限甚至局灶性病变消融。在聚焦治疗期间可使用多种能量类型。首先，聚焦治疗可大致分为热能与非热能。本非系统性综述的目的是对最近关于前列腺癌聚焦治疗的现有证据进行全面分析。
