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前列腺癌的聚焦治疗

Focal therapy for prostate cancer.

作者信息

Basseri Sana, Perlis Nathan, Ghai Sangeet

机构信息

Division of Abdominal Radiology, Joint Department of Medical Imaging, University Health Network - Mt Sinai Hospital - Women's College Hospital - University of Toronto, Toronto, ON, Canada.

Division of Urology, Department of Surgical Oncology, University Health Network, University of Toronto, Toronto, ON, Canada.

出版信息

Abdom Radiol (NY). 2025 Feb;50(2):757-769. doi: 10.1007/s00261-024-04482-7. Epub 2024 Aug 20.

Abstract

Traditional treatments for localized prostate cancer include radical prostatectomy or radiation therapy but pose challenges due to treatment related side effects, namely erectile dysfunction and urinary incontinence. In recent years, focal therapy has emerged as a viable treatment option for localized low-intermediate risk prostate cancer in carefully selected patients. Short and medium-term studies show acceptable cancer control outcomes and reduced morbidity when comparing focal therapy to whole gland treatment for prostate cancer, however there is paucity of long-term studies. Here we review focal ablative therapies commonly used, discuss the role of imaging in monitoring treatment, and summarize oncologic outcomes based on studies to date.

摘要

局限性前列腺癌的传统治疗方法包括根治性前列腺切除术或放射治疗,但由于治疗相关的副作用,即勃起功能障碍和尿失禁,这些方法存在挑战。近年来,聚焦治疗已成为经过精心挑选的局限性低中危前列腺癌患者的一种可行治疗选择。短期和中期研究表明,与前列腺癌的全腺治疗相比,聚焦治疗的癌症控制结果可接受且发病率降低,然而长期研究较少。在此,我们回顾常用的聚焦消融疗法,讨论成像在监测治疗中的作用,并根据迄今为止的研究总结肿瘤学结果。

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