Matějková Jana, Kaňoková Denisa, Matějka Roman
Department of Biomedical Technology, Faculty of Biomedical Engineering, Czech Technical University in Prague, 27201 Kladno, Czech Republic.
Gels. 2024 Dec 26;11(1):4. doi: 10.3390/gels11010004.
Cardiovascular disease is one of the leading causes of death and serious illness in Europe and worldwide. Conventional treatment-replacing the damaged blood vessel with an autologous graft-is not always affordable for the patient, so alternative approaches are being sought. One such approach is patient-specific tissue bioprinting, which allows for precise distribution of cells, material, and biochemical signals. With further developmental support, a functional replacement tissue or vessel can be created. This review provides an overview of the current state of bioprinting for vascular graft manufacturing and summarizes the hydrogels used as bioinks, the material of carriers, and the current methods of fabrication used, especially for vessels smaller than 6 mm, which are the most challenging for cardiovascular replacements. The fabrication methods are divided into several sections-self-supporting grafts based on simple 3D bioprinting and bioprinting of bioinks on scaffolds made of decellularized or nanofibrous material.
心血管疾病是欧洲乃至全球主要的死亡和重病原因之一。传统治疗方法——用自体移植物替换受损血管——对患者来说并不总是负担得起，因此人们正在寻找替代方法。其中一种方法是个性化组织生物打印，它能够精确地分布细胞、材料和生化信号。在进一步的研发支持下，可以制造出功能性替代组织或血管。本文综述了用于血管移植物制造的生物打印的当前状态，总结了用作生物墨水的水凝胶、载体材料以及当前使用的制造方法，特别是对于小于6毫米的血管，这是心血管替代物中最具挑战性的。制造方法分为几个部分——基于简单3D生物打印的自支撑移植物以及在由脱细胞或纳米纤维材料制成的支架上进行生物墨水的生物打印。
