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用于慢性伤口愈合的藻酸盐水凝胶珠中加载的提取物

Extract Loaded in Alginate Hydrogel Beads for Chronic Wound Healing.

作者信息

Bâldea Ioana, Soran Maria-Loredana, Stegarescu Adina, Opriș Ocsana, Kacso Irina, Tripon Septimiu, Adascalitei Alexandra, Fericel Iulian George, Decea Roxana, Lung Ildiko

机构信息

Department of Physiology, Iuliu Haţieganu University of Medicine and Pharmacy, Clinicilor 1, 400006 Cluj-Napoca, Romania.

National Institute for Research and Development of Isotopic and Molecular Technologies, 67-103 Donath, 400293 Cluj-Napoca, Romania.

出版信息

Gels. 2025 Jan 1;11(1):22. doi: 10.3390/gels11010022.

DOI:10.3390/gels11010022
PMID:39851993
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11765094/
Abstract

Chronic wounds are a major health problem, affecting millions of people worldwide. Resistance to treatment is frequently observed, requiring an extension of the wound healing time, and improper care can lead to more problems in patients. Smart wound dressings that provide a controlled drug release can significantly improve the healing process. In this paper, alginate beads with white lily leaf extract were prepared and tested for chronic wound healing. The obtained beads were characterized by scanning electron microscopy (SEM) and Fourier transform infrared spectroscopy (FTIR). Also, the efficiency of extract encapsulation in alginate was determined as being of. The obtained hydrogel was tested on two normal human cell lines, respectively, dermal fibroblasts (BJ-CRL-2522-ATCC) and endothelial cells (human umbilical vein endothelial cells-HUVEC 2). The longer release of bioactive compounds from plant extract loaded in the alginate hydrogel resulted in more effective wound closure, compared to the extract alone, and scar formation, compared to the alginate hydrogel. Therefore, the effect of the white lily extract in combination with that of sodium alginate hydrogel improves the biological activity of the alginate hydrogel and increases the wound healing properties of the alginate.

摘要

慢性伤口是一个重大的健康问题，影响着全球数百万人。经常观察到对治疗的抵抗性，这需要延长伤口愈合时间，并且护理不当会给患者带来更多问题。能够实现可控药物释放的智能伤口敷料可以显著改善愈合过程。在本文中，制备了含有白百合叶提取物的藻酸盐珠，并对其进行慢性伤口愈合测试。通过扫描电子显微镜（SEM）和傅里叶变换红外光谱（FTIR）对所得珠子进行表征。此外，确定藻酸盐中提取物的包封效率为 。将所得水凝胶分别在两种正常人细胞系上进行测试，即真皮成纤维细胞（BJ - CRL - 2522 - ATCC）和内皮细胞（人脐静脉内皮细胞 - HUVEC 2）。与单独的提取物相比，负载在藻酸盐水凝胶中的植物提取物中生物活性化合物的更长时间释放导致更有效的伤口闭合，与藻酸盐水凝胶相比，瘢痕形成更少。因此，白百合提取物与海藻酸钠水凝胶的联合作用提高了藻酸盐水凝胶的生物活性，并增强了藻酸盐的伤口愈合性能。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2bcc/11765094/36fbf06fc7dc/gels-11-00022-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2bcc/11765094/d9974fd36684/gels-11-00022-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2bcc/11765094/91d803847304/gels-11-00022-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2bcc/11765094/e3974f3d3f8e/gels-11-00022-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2bcc/11765094/6979b1552e02/gels-11-00022-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2bcc/11765094/f64e4530f087/gels-11-00022-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2bcc/11765094/c6b730c7157c/gels-11-00022-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2bcc/11765094/6374b77239b7/gels-11-00022-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2bcc/11765094/0d26e3ca3548/gels-11-00022-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2bcc/11765094/36fbf06fc7dc/gels-11-00022-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2bcc/11765094/d9974fd36684/gels-11-00022-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2bcc/11765094/91d803847304/gels-11-00022-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2bcc/11765094/e3974f3d3f8e/gels-11-00022-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2bcc/11765094/6979b1552e02/gels-11-00022-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2bcc/11765094/f64e4530f087/gels-11-00022-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2bcc/11765094/c6b730c7157c/gels-11-00022-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2bcc/11765094/6374b77239b7/gels-11-00022-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2bcc/11765094/0d26e3ca3548/gels-11-00022-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2bcc/11765094/36fbf06fc7dc/gels-11-00022-g009.jpg

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