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透明质酸凝胶填充剂用于身体塑形的形态学和流变学特性分析及其临床相关性

Analysis of Morphologic and Rheological Properties of Hyaluronic Acid Gel Fillers to Body Contouring and Its Clinical Correlation.

作者信息

Issa Maria Cláudia Almeida, Viana Renata M M, de Souza Mendes Paulo R, Naccache Mônica F, Varges Priscila R, Castaño Eliana P Marín, Palermo Eliandre

机构信息

Department of Internal Medicine (Dermatology), Universidade Federal Fluminense, Niterói 24033-900, RJ, Brazil.

Private Practice, São Paulo 04012-080, SP, Brazil.

出版信息

Gels. 2025 Jan 15;11(1):65. doi: 10.3390/gels11010065.

Abstract

The demand for minimally invasive body contouring procedures, particularly for gluteal augmentation, has grown significantly. This study evaluates the morphologic and rheological properties of four commercially available hyaluronic acid (HA) fillers used for body contouring and explores their clinical implications. Critical parameters such as storage modulus (G'), loss modulus (G″), complex modulus (G*), and damping factor (tan δ) were measured using oscillatory rheological tests to assess each filler's elasticity, viscosity, and viscoelastic profile. Scanning Electron Microscopy (SEM) was performed to analyze the microstructure of the fillers, providing insights into their microscopic architecture. The results showed differences in mechanical properties and viscoelastic behavior among the fillers. These variations suggest that the choice of filler may need to be tailored to specific body contouring requirements. Understanding these differences is crucial for achieving the best clinical results and patient satisfaction, helping professionals select the most suitable filler for each case.

摘要

对微创身体塑形手术的需求,尤其是对臀部增大手术的需求显著增长。本研究评估了四种用于身体塑形的市售透明质酸(HA)填充剂的形态学和流变学特性,并探讨了它们的临床意义。使用振荡流变测试测量了储能模量(G')、损耗模量(G'')、复数模量(G*)和阻尼因子(tan δ)等关键参数,以评估每种填充剂的弹性、粘度和粘弹性特征。进行扫描电子显微镜(SEM)分析以研究填充剂的微观结构,从而深入了解其微观架构。结果显示填充剂之间在力学性能和粘弹性行为方面存在差异。这些差异表明,可能需要根据特定的身体塑形要求来选择填充剂。了解这些差异对于获得最佳临床效果和患者满意度至关重要,有助于专业人员为每个病例选择最合适的填充剂。

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