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使用秘鲁玛卡联合YAP-1和PARP-1抑制剂治疗多形性胶质母细胞瘤的疗效及机制的理论研究

A Theoretical Study on the Efficacy and Mechanism of Combined YAP-1 and PARP-1 Inhibitors in the Treatment of Glioblastoma Multiforme Using Peruvian Maca .

作者信息

Turpo-Peqqueña Albert Gabriel, Luna-Prado Sebastian, Valencia-Arce Renato Javier, Del-Carpio-Carrazco Fabio Leonardo, Gómez Badhin

机构信息

Centro de Investigación en Ingeniería Molecular-CIIM, Universidad Católica de Santa María, Urb. San José s/n, Umacollo, Arequipa 04013, Peru.

Facultad de Medicina Humana, Universidad Católica de Santa María, Urb. San José s/n, Umacollo, Arequipa 04013, Peru.

出版信息

Curr Issues Mol Biol. 2025 Jan 9;47(1):40. doi: 10.3390/cimb47010040.

DOI:10.3390/cimb47010040
PMID:39852155
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11763394/
Abstract

Glioblastoma multiforme (GBM) is one of the most aggressive and treatment-resistant forms of brain cancer. Current therapeutic strategies, including surgery, chemotherapy, and radiotherapy, often fail due to the tumor's ability to develop resistance. The proteins YAP-1 (Yes-associated protein 1) and PARP-1 (Poly-(ADP-ribose)-polymerase-1) have been implicated in this resistance, playing crucial roles in cell proliferation and DNA repair mechanisms, respectively. This study explored the inhibitory potential of natural compounds from (Peruvian Maca) on the YAP-1 and PARP-1 protein systems to develop novel therapeutic strategies for GBM. By molecular dynamics simulations, we identified N-(3-Methoxybenzyl)-(9Z,12Z,15Z)- octadecatrienamide (DK5) as the most promising natural inhibitor for PARP-1 and stearic acid (GK4) for YAP-1. Although synthetic inhibitors, such as Olaparib (ODK) for PARP-1 and Verteporfin (VER) for YAP-1, only VER was superior to the naturally occurring molecule and proved a promising alternative. In conclusion, natural compounds from (Peruvian Maca) offer a potentially innovative approach to improve GBM treatment, complementing existing therapies with their inhibitory action on PARP-1 and YAP-1.

摘要

多形性胶质母细胞瘤（GBM）是最具侵袭性且最难治疗的脑癌形式之一。目前的治疗策略，包括手术、化疗和放疗，常常因肿瘤产生耐药性而失败。蛋白质YAP-1（Yes相关蛋白1）和PARP-1（聚（ADP-核糖）聚合酶-1）与这种耐药性有关，分别在细胞增殖和DNA修复机制中发挥关键作用。本研究探索了秘鲁玛卡中的天然化合物对YAP-1和PARP-1蛋白系统的抑制潜力，以开发针对GBM的新型治疗策略。通过分子动力学模拟，我们确定N-（3-甲氧基苄基）-（9Z，12Z，15Z）-十八碳三烯酰胺（DK5）是PARP-1最有前景的天然抑制剂，而硬脂酸（GK4）是YAP-1的最有前景的天然抑制剂。虽然PARP-1的合成抑制剂奥拉帕尼（ODK）和YAP-1的维替泊芬（VER）中，只有VER优于天然存在的分子，并被证明是一种有前景的替代物。总之，秘鲁玛卡中的天然化合物为改善GBM治疗提供了一种潜在的创新方法，通过对PARP-1和YAP-1的抑制作用来补充现有疗法。

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2
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J Neurooncol. 2023 Dec;165(3):499-507. doi: 10.1007/s11060-023-04514-0. Epub 2023 Nov 28.
3
Advances in Glioblastoma Therapy: An Update on Current Approaches.
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Brain Sci. 2023 Oct 31;13(11):1536. doi: 10.3390/brainsci13111536.
4
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5
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10
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