Olsen Stine S H, Afoullouss Sam, Cruz Rosa Ezequiel, Young Ryan M, Johnson Mark, Allcock A Louise, Baker Bill J
Department of Chemistry, University of South Florida, 4202 E. Fowler Avenue, CHE205, Tampa, FL 33620, USA.
School of Natural Sciences and Ryan Institute, University of Galway, University Road, H91TK33 Galway, Ireland.
Mar Drugs. 2025 Jan 17;23(1):44. doi: 10.3390/md23010044.
New technology has opened opportunities for research and exploration of deep-water ecosystems, highlighting deep-sea coral reefs as a rich source of novel bioactive natural products. During our ongoing investigation of the chemodiversity of the Irish deep sea and the soft coral we report 12 unreported cadinene-like functionalized sesquiterpenes, anthoteibinenes F-Q. The metabolites were isolated using both bioassay- and H NMR-guided approaches. One-/two-dimensional NMR spectroscopy and high-resolution mass spectrometry were used for structure elucidation, while a combination of NOESY NMR experiments, GIAO NMR calculations coupled with DP4+ probabilities measures, and ECD comparisons were incorporated to propose relative and absolute configurations of the anthoteibinenes. The metabolites were screened against the Respiratory Syncytial Virus (RSV), ESKAPE pathogens, five strains, and one strain of .
新技术为研究和探索深水生态系统带来了机遇，突出了深海珊瑚礁作为新型生物活性天然产物的丰富来源。在我们对爱尔兰深海和软珊瑚化学多样性的持续研究中，我们报道了12种未报道的类杜松烯官能化倍半萜，即anthoteibinenes F-Q。这些代谢产物采用生物测定和氢核磁共振引导的方法进行分离。利用一维/二维核磁共振光谱和高分辨率质谱进行结构解析，同时结合核欧沃豪斯效应核磁共振实验、GIAO核磁共振计算以及DP4+概率测量和电子圆二色性比较来确定anthoteibinenes的相对和绝对构型。对这些代谢产物针对呼吸道合胞病毒（RSV）、ESKAPE病原体、五种菌株和一种……菌株进行了筛选。
