双氧化卡拉门烯：一种来自软珊瑚黄斑皱叶珊瑚的双倍半萜。

Trifman Yuval J, Aknin Maurice, Gauvin-Bialecki Anne, Benayahu Yehuda, Carmeli Shmuel, Kashman Yoel

School of Chemistry, Raymond and Beverly Sackler Faculty of Exact Sciences, Tel Aviv University, Tel Aviv 69978, Israel.

Laboratory of Chemistry of Natural Substances and Food Sciences, Faculty of Science and Technology, University of Reunion Island, 15 Avenue René Cassin, CS 92003, 97744 Saint-Denis Cedex 9, La Reunion, France.

Mar Drugs. 2016 Feb 19;14(2):41. doi: 10.3390/md14020041.

A dichloromethane extract of the soft coral Rhytisma fulvum fulvum collected in Madagascar afforded a novel compound possessing an unprecedented pentacyclic skeleton, bisdioxycalamenene (1), as well as seven known sesquiterpenes. The structures of the compounds were elucidated using 1D and 2D NMR techniques, as well as high-resolution mass spectrometry. The absolute configuration of 1 was determined using X-ray diffraction analysis and anomalous dispersion effects. The structure elucidation and a possible biogenesis of the compound are discussed.

从马达加斯加采集的软珊瑚Rhytisma fulvum fulvum的二氯甲烷提取物中得到了一种具有前所未有的五环骨架的新型化合物双二氧卡拉烯（1），以及七种已知的倍半萜。使用一维和二维核磁共振技术以及高分辨率质谱对这些化合物的结构进行了阐明。通过X射线衍射分析和反常色散效应确定了1的绝对构型。讨论了该化合物的结构阐明和可能的生源合成。