Chaikof E L, McCabe C J
Am J Surg. 1985 Apr;149(4):534-9. doi: 10.1016/s0002-9610(85)80052-0.
A total of 776 patients underwent splenectomy at the Massachusetts General Hospital between 1962 and 1972. Follow-up information was obtained on 637 patients (82 percent), including 584 adults and 53 children. There was a total of 4,837 person-years of follow-up with a mean observation interval of 8.4 years. Four cases of fatal overwhelming postsplenectomy infection were identified. In our pediatric population, the incidence of fatal overwhelming postsplenectomy infection was 3.77 percent, which was significantly higher than the incidence of 0.34 percent in our asplenic adults. Overwhelming postsplenectomy infection is a unique clinical entity distinguishable from other infections. It may occur during the lifetime of any asplenic patient and especially in those patients who have had a splenectomy in childhood. In asplenic adults, the incidence is low. The aggressive approach to splenic preservation in the adult should be tempered by these results.
1962年至1972年间，共有776例患者在马萨诸塞州总医院接受了脾切除术。获得了637例患者（82%）的随访信息，其中包括584名成年人和53名儿童。总随访人年数为4837人年，平均观察间隔为8.4年。确定了4例脾切除术后暴发性感染致死病例。在我们的儿科人群中，脾切除术后暴发性感染致死的发生率为3.77%，显著高于无脾成年人0.34%的发生率。脾切除术后暴发性感染是一种有别于其他感染的独特临床病症。它可能发生在任何无脾患者的一生中，尤其是那些童年时期接受过脾切除术的患者。在无脾成年人中，发生率较低。这些结果应使成人脾保留的积极方法有所缓和。
