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绿原酸对雷公藤多苷致大鼠弱精子症的治疗作用及其机制探讨

Efficacy of Chlorogenic Acid in Treating Tripterygium Glycoside-Induced Asthenozoospermia in Rats and Its Possible Mechanisms.

作者信息

Chen Long, Bello-Onaghise God'spower, Chen Mo, Li Shunda, Zhang Yu, Wang Haoran, Qu Qianwei, Li Yanhua

机构信息

College of Veterinary Medicine, Northeast Agricultural University, 600 Changjiang Road, Xiangfang, Harbin 150030, China.

Department of Animal Science, Faculty of Agriculture, University of Benin, Benin City 300103, Nigeria.

出版信息

Vet Sci. 2025 Jan 16;12(1):66. doi: 10.3390/vetsci12010066.

DOI:10.3390/vetsci12010066
PMID:39852941
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11768533/
Abstract

Tripterygium glycosides (TGs) are the most common form of traditional Chinese medicine, known as Tripterygium wilfordii Hook F (TWHF) [...].

摘要

雷公藤多苷（TGs）是最常见的一种中药，即雷公藤（TWHF）[...]。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7b8/11768533/9c254da79763/vetsci-12-00066-g007a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7b8/11768533/4d0d236b550d/vetsci-12-00066-g001.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7b8/11768533/da1d988323a3/vetsci-12-00066-g003.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7b8/11768533/7a0cff2269d8/vetsci-12-00066-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7b8/11768533/21e4738db4d9/vetsci-12-00066-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7b8/11768533/9c254da79763/vetsci-12-00066-g007a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7b8/11768533/4d0d236b550d/vetsci-12-00066-g001.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7b8/11768533/da1d988323a3/vetsci-12-00066-g003.jpg
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Efficacy of Chlorogenic Acid in Treating Tripterygium Glycoside-Induced Asthenozoospermia in Rats and Its Possible Mechanisms.绿原酸对雷公藤多苷致大鼠弱精子症的治疗作用及其机制探讨
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本文引用的文献

1
The influence of rutin and chlorogenic acid on oxidative stress and in vivo fertility: Evaluation of the quality and antioxidant status of post-thaw semen from Azari water buffalo bulls.芦丁和绿原酸对氧化应激和体内生育力的影响：评估阿扎里水牛公牛冻融后精液的质量和抗氧化状态。
Vet Med Sci. 2024 Sep;10(5):e31548. doi: 10.1002/vms3.1548.
2
Triptolide induced spermatogenesis dysfunction via ferroptosis activation by promoting K63-linked GPX4 polyubiquitination in spermatocytes.雷公藤红素通过促进精母细胞中 K63 连接的 GPX4 多聚泛素化来激活铁死亡导致精子发生功能障碍。
Chem Biol Interact. 2024 Aug 25;399:111130. doi: 10.1016/j.cbi.2024.111130. Epub 2024 Jul 2.
3
Chlorogenic acid can improve spermatogenic dysfunction in rats with varicocele by regulating mitochondrial homeostasis and inhibiting the activation of NLRP3 inflammasomes by oxidative mitochondrial DNA and cGAS/STING pathway.
绿原酸可以通过调节线粒体稳态和抑制氧化线粒体 DNA 和 cGAS/STING 通路激活 NLRP3 炎性体来改善精索静脉曲张大鼠的生精功能障碍。
Bioorg Chem. 2024 Sep;150:107571. doi: 10.1016/j.bioorg.2024.107571. Epub 2024 Jun 17.
4
Chlorogenic Acid: A Systematic Review on the Biological Functions, Mechanistic Actions, and Therapeutic Potentials.绿原酸：生物功能、作用机制和治疗潜力的系统评价。
Nutrients. 2024 Mar 23;16(7):924. doi: 10.3390/nu16070924.
5
Prevalence of Abnormal Semen Parameters among the Infertile Couples Seeking Infertility Treatment.不孕夫妇中寻求不孕治疗的精液参数异常的流行率。
Mymensingh Med J. 2024 Apr;33(2):586-591.
6
The effects of L-carnitine supplementation on inflammation, oxidative stress, and clinical outcomes in critically Ill patients with sepsis: a randomized, double-blind, controlled trial.左旋肉碱补充对脓毒症危重症患者炎症、氧化应激和临床结局的影响：一项随机、双盲、对照试验。
Nutr J. 2024 Mar 6;23(1):31. doi: 10.1186/s12937-024-00934-4.
7
Moxibustion prevents tripterygium glycoside-induced oligoasthenoteratozoospermia in rats via reduced oxidative stress and modulation of the Nrf2/HO-1 signaling pathway.艾灸通过降低氧化应激和调节 Nrf2/HO-1 信号通路预防雷公藤苷致大鼠少弱畸形精子症。
Aging (Albany NY). 2024 Jan 25;16(3):2141-2160. doi: 10.18632/aging.205475.
8
A Dietary Supplement Jinghuosu Ameliorates Reproductive Damage Induced by Tripterygium Glycosides.一种膳食补充剂京胡素可改善雷公藤苷诱导的生殖损伤。
Chin J Integr Med. 2024 Apr;30(4):330-338. doi: 10.1007/s11655-023-3750-9. Epub 2024 Jan 12.
9
Antioxidant potential of chlorogenic acid in Age-Related eye diseases.绿原酸在年龄相关性眼病中的抗氧化潜力。
Pharmacol Res Perspect. 2024 Feb;12(1):e1162. doi: 10.1002/prp2.1162.
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The protective role of L-carnitine on oxidative stress, neurotransmitter perturbations, astrogliosis, and apoptosis induced by thiamethoxam in the brains of male rats.左卡尼汀对噻虫嗪诱导雄性大鼠大脑氧化应激、神经递质紊乱、星形胶质细胞增生和细胞凋亡的保护作用。
Naunyn Schmiedebergs Arch Pharmacol. 2024 Jun;397(6):4365-4379. doi: 10.1007/s00210-023-02887-7. Epub 2023 Dec 15.