Singh Gurfarmaan, Lee Yong Min, Sun Michelle, Selva Dinesh, Chan WengOnn
The University of Adelaide, North Terrace, Adelaide, SA, 5000, Australia.
Department of Ophthalmology, Royal Adelaide Hospital, Port Road, Adelaide, SA, 5000, Australia.
Int Ophthalmol. 2025 Jan 24;45(1):37. doi: 10.1007/s10792-025-03407-7.
To characterize the anterior segment (AS) morphology of patients with long-term silicone oil (SiO) in situ (> 12 months) following pars plana vitrectomy (PPV).
This prospective, comparative characterization study was conducted between January 2022 and July 2023. Patients were included and sorted based on if they had undergone PPV without long-term SiO or had SiO in situ for at least 12 months at the time of review and image collection. The Zeiss Cirrus HD-OCT (Carl Zeiss, Dublin, California, USA) was employed to image the ASs of study patients. Software within the OCT was used to collect the central corneal thickness (CCT), anterior chamber diameter (ACd), anterior chamber depth (ACD), chamber area, temporal irideocorneal angle and nasal irideocorneal angle.
A total of 78 eyes from 42 total patients were included, their mean age was 63.74 ± 19.13 years and 64.29% (27/42) of participants were males. Patients who underwent PPV with and without long-term SiO were found to have no significant difference in CCT, ACd, ACD, chamber area and irideocorneal angles compared to their fellow unoperated eyes. The multivariate analysis of variance of the pooled data noted a statistically significant difference in the ACd of PPV with long-term SiO eyes compared to PPV without long-term SiO and unoperated eyes (p = < 0.001).
These findings suggest PPV with long-term SiO may alter the AS morphology of patients, its influence on the development of OAG remains unclear and warrants further investigation.
描述玻璃体切割术后长期（> 12个月）硅油原位填充患者的眼前节（AS）形态。
本前瞻性比较特征研究于2022年1月至2023年7月进行。根据患者是否接受过无长期硅油填充的玻璃体切割术，或在复查和图像采集时硅油原位填充至少12个月，将患者纳入并分类。使用蔡司Cirrus HD-OCT（美国加利福尼亚州都柏林的卡尔蔡司公司）对研究患者的眼前节进行成像。使用OCT软件收集中央角膜厚度（CCT）、前房直径（ACd）、前房深度（ACD）、房面积、颞侧虹膜角膜角和鼻侧虹膜角膜角。
共纳入42例患者的78只眼，平均年龄为63.74±19.13岁，64.29%（27/42）的参与者为男性。与未手术的对侧眼相比，接受有或无长期硅油填充的玻璃体切割术的患者在CCT、ACd、ACD、房面积和虹膜角膜角方面无显著差异。对汇总数据进行的多变量方差分析指出，与未进行长期硅油填充的玻璃体切割术和未手术的眼相比，长期硅油填充的玻璃体切割术患者的ACd存在统计学显著差异（p = < 0.001）。
这些发现表明，长期硅油填充的玻璃体切割术可能会改变患者的眼前节形态，其对开角型青光眼发展的影响尚不清楚，值得进一步研究。
