Hazan Hadar, Funaro Melissa C, Srihari Vinod H
Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, United States of America.
Program for Specialized Treatment Early in Psychosis (STEP), Connecticut Mental Health, New Haven, Connecticut, United States of America.
PLoS One. 2025 Jan 24;20(1):e0316447. doi: 10.1371/journal.pone.0316447. eCollection 2025.
Insight in psychosis, defined as a patient's awareness and judgment of their mental illness, is a complex and evolving concept. Historically, the absence of insight was considered a defining characteristic of psychosis, but recent decades have seen the development of structured tools for its assessment. This systematic review aims to critically appraise the measurement properties of instruments used to assess insight in individuals with schizophrenia spectrum, bridging the gap between theoretical conceptualization and clinical practice.
This protocol is reported following the Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols (PRISMA-P) guidelines. Eligible studies will evaluate instruments measuring insight in psychosis, including self-report, observer ratings, behavioral measurements, and semi-structured interviews. The psychometric properties assessed will encompass reliability, validity, responsiveness, interpretability, and clinical utility. We will include primary quantitative studies published in peer-reviewed journals and available in English.
Two reviewers will conduct data extraction and quality assessment independently, with discrepancies resolved through consensus or a third reviewer. The COSMIN Risk of Bias checklist and the GRADE approach will be used to evaluate each measure's methodological quality and overall strength of evidence.
This systematic review will synthesize current evidence on insight measurement in psychosis, providing a comprehensive overview of the strengths and limitations of existing instruments. The findings will inform future research and clinical practice, facilitating the selection of the most appropriate tools for assessing insight and ultimately contributing to improved care for individuals with psychosis. The findings will provide clinicians and researchers with robust tools for assessing insight, ultimately enhancing treatment outcomes for individuals with psychosis.
对精神病的洞察力,定义为患者对自身精神疾病的认识和判断,是一个复杂且不断发展的概念。历史上,缺乏洞察力被视为精神病的一个决定性特征,但近几十年来出现了用于评估洞察力的结构化工具。本系统评价旨在批判性地评估用于评估精神分裂症谱系个体洞察力的工具的测量属性,弥合理论概念化与临床实践之间的差距。
本方案按照系统评价与Meta分析方案的首选报告项目(PRISMA-P)指南进行报告。符合条件的研究将评估测量精神病洞察力的工具,包括自我报告、观察者评分、行为测量和半结构化访谈。评估的心理测量属性将包括信度、效度、反应度、可解释性和临床实用性。我们将纳入发表在同行评审期刊且为英文的原发性定量研究。
两名评审员将独立进行数据提取和质量评估,分歧通过协商一致或由第三名评审员解决。将使用COSMIN偏倚风险清单和GRADE方法来评估每项测量的方法学质量和证据的总体强度。
本系统评价将综合当前关于精神病洞察力测量的证据,全面概述现有工具的优点和局限性。研究结果将为未来的研究和临床实践提供信息,有助于选择最合适的工具来评估洞察力,并最终为改善精神病患者的护理做出贡献。研究结果将为临床医生和研究人员提供评估洞察力的有力工具,最终提高精神病患者的治疗效果。