Del Percio Claudio, Lizio Roberta, Lopez Susanna, Noce Giuseppe, Jakhar Dharmendra, Carpi Matteo, Bölükbaş Burcu, Soricelli Andrea, Salvatore Marco, Güntekin Bahar, Yener Görsev, Massa Federico, Arnaldi Dario, Famà Francesco, Pardini Matteo, Ferri Raffaele, Salerni Michele, Lanuzza Bartolo, Stocchi Fabrizio, Vacca Laura, Coletti Chiara, Marizzoni Moira, Taylor John Paul, Hanoğlu Lutfu, Helvacı Yılmaz Nesrin, Kıyı İlayda, Özbek-İşbitiren Yağmur, Frisoni Giovanni B, Cuoco Sofia, Barone Paolo, D'Anselmo Anita, Bonanni Laura, Biundo Roberta, D'Antonio Fabrizia, Bruno Giuseppe, Giubilei Franco, De Pandis Francesca, Rotondo Rossella, Antonini Angelo, Babiloni Claudio
Department of Physiology and Pharmacology "Vittorio Erspamer", Sapienza University of Rome, Rome, Italy.
Department of Physiology and Pharmacology "Vittorio Erspamer", Sapienza University of Rome, Rome, Italy; Oasi Research Institute - IRCCS, Troina, Italy.
Neurobiol Dis. 2025 Mar;206:106807. doi: 10.1016/j.nbd.2025.106807. Epub 2025 Jan 22.
Parkinson's disease with dementia (PDD) and dementia with Lewy bodies (DLB) are more prevalent in males than females. Furthermore, they typically showed abnormally high delta (< 4 Hz) and low alpha (8-10 Hz) rhythms from resting-state electroencephalographic (rsEEG) activity. Here, we hypothesized that those abnormalities may depend on the patient's sex. An international database provided clinical-demographic-rsEEG datasets for cognitively unimpaired older (Healthy; N = 49; 24 females), PDD (N = 39; 13 females), and DLB (N = 38; 15 females) participants. Each group was stratified into matched female and male subgroups. The rsEEG rhythms were investigated across the individual rsEEG delta, theta, and alpha frequency bands based on the individual alpha frequency peak. The eLORETA freeware was used to estimate cortical rsEEG sources. In the Healthy group, widespread rsEEG alpha source activities were greater in the females than in the males. In the PDD group, widespread rsEEG delta source activities were lower and widespread rsEEG alpha source activities were greater in the females than in the males. In the DLB group, central-parietal rsEEG delta source activities were lower, and posterior rsEEG alpha source activities were greater in the females than in the males. These results suggest sex-dependent hormonal modulation of neuroprotective-compensatory neurophysiological mechanisms in PDD and DLB patients underlying the generation of rsEEG delta and alpha rhythms, which should be considered in the treatment of vigilance dysregulation in those patients.
帕金森病痴呆（PDD）和路易体痴呆（DLB）在男性中比在女性中更为普遍。此外，他们静息态脑电图（rsEEG）活动通常显示出异常高的δ波（<4Hz）和低的α波（8 - 10Hz）节律。在此，我们假设这些异常可能取决于患者的性别。一个国际数据库提供了认知未受损的老年人（健康组；N = 49；24名女性）、PDD患者（N = 39；13名女性）和DLB患者（N = 38；15名女性）的临床 - 人口统计学 - rsEEG数据集。每个组被分层为匹配的女性和男性亚组。基于个体α频率峰值，在个体rsEEG的δ波、θ波和α波频段上研究rsEEG节律。使用eLORETA免费软件估计皮层rsEEG源。在健康组中，女性的广泛rsEEGα源活动比男性更大。在PDD组中，女性的广泛rsEEGδ源活动更低，广泛rsEEGα源活动比男性更大。在DLB组中，女性的中央 - 顶叶rsEEGδ源活动更低，后部rsEEGα源活动比男性更大。这些结果表明，PDD和DLB患者中rsEEGδ波和α波节律产生背后的神经保护 - 代偿性神经生理机制存在性别依赖性激素调节，在治疗这些患者的警觉失调时应予以考虑。
