• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

鉴定胃癌中与细胞衰老相关的长链非编码RNA LINC01579

Identification the Cellular Senescence Associated lncRNA LINC01579 in Gastric Cancer.

作者信息

He Jiayong, Fu Ziyi, Zou Boya, Lei Xuetao, Lei Linhan, Yang Qingbin, Li Guoxin

机构信息

Department of General Surgery, Nanfang Hospital, Southern Medical University, Guangdong Provincial Engineering Technology Research Center of Minimally Invasive Surgery, Guangzhou, People's Republic of China.

Guangdong Provincial Key Laboratory of Precision Medicine for Gastrointestinal Tumor, Guangzhou, People's Republic of China.

出版信息

J Cell Mol Med. 2025 Jan;29(2):e70360. doi: 10.1111/jcmm.70360.

DOI:10.1111/jcmm.70360
PMID:39855898
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11760997/
Abstract

Cellular senescence is a key promoter of tumorigenesis and malignant progression. This study aimed to develop a predictive model for assessing cellular senescence in gastric cancer (GC) outcomes. We identified senescence-related genes and lncRNAs from 375 stomach adenocarcinoma (STAD) patients and established a prognostic senescence score using multivariate Cox regression, validated in testing, TCGA-STAD and the combined TCGA-COAD and READ cohorts. The model's predictive efficacy was evaluated across clinical subgroups, tumour microenvironments and immune cell infiltration. A total of 116 senescence-related lncRNAs were filtered, and patients were clustered into two senescent subtypes. The lncRNA signature identified LINC01579 as an independent prognostic factor for GC. Low-risk groups showed prolonged overall survival, increased immune cell infiltration and reduced mutation load. Downregulation of LINC01579 using antisense oligonucleotides (ASOs) on normal human fibroblasts decreased cellular proliferation and migration in GC. Collectively, this study established and validated a promising prognostic model connecting senescence-related lncRNAs and clinical outcome in GC and provided potential senescence-related biomarkers for GC prognosis prediction.

摘要

细胞衰老 是肿瘤发生和恶性进展的关键促进因素。本研究旨在建立一种预测模型，用于评估胃癌（GC）预后中的细胞衰老情况。我们从375例胃腺癌（STAD）患者中鉴定出衰老相关基因和长链非编码RNA（lncRNA），并使用多变量Cox回归建立了预后衰老评分，在测试队列、TCGA-STAD队列以及合并的TCGA-COAD和READ队列中进行了验证。在不同临床亚组、肿瘤微环境和免疫细胞浸润中评估了该模型的预测效能。共筛选出116个衰老相关lncRNA，并将患者聚类为两种衰老亚型。lncRNA特征鉴定出LINC01579为GC的独立预后因素。低风险组显示总生存期延长、免疫细胞浸润增加且突变负荷降低。在正常人成纤维细胞上使用反义寡核苷酸（ASO）下调LINC01579可降低GC中的细胞增殖和迁移。总体而言，本研究建立并验证了一个有前景的预后模型，该模型将衰老相关lncRNA与GC的临床结局联系起来，并为GC预后预测提供了潜在的衰老相关生物标志物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a986/11760997/4734cc3a1258/JCMM-29-e70360-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a986/11760997/aa0d76c6a7e6/JCMM-29-e70360-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a986/11760997/57531358236e/JCMM-29-e70360-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a986/11760997/1cb77ae6ce78/JCMM-29-e70360-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a986/11760997/1799fd7eaf8d/JCMM-29-e70360-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a986/11760997/6ed8629994a7/JCMM-29-e70360-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a986/11760997/021c45faedd8/JCMM-29-e70360-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a986/11760997/4734cc3a1258/JCMM-29-e70360-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a986/11760997/aa0d76c6a7e6/JCMM-29-e70360-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a986/11760997/57531358236e/JCMM-29-e70360-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a986/11760997/1cb77ae6ce78/JCMM-29-e70360-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a986/11760997/1799fd7eaf8d/JCMM-29-e70360-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a986/11760997/6ed8629994a7/JCMM-29-e70360-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a986/11760997/021c45faedd8/JCMM-29-e70360-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a986/11760997/4734cc3a1258/JCMM-29-e70360-g002.jpg

相似文献

1
Identification the Cellular Senescence Associated lncRNA LINC01579 in Gastric Cancer.鉴定胃癌中与细胞衰老相关的长链非编码RNA LINC01579
J Cell Mol Med. 2025 Jan;29(2):e70360. doi: 10.1111/jcmm.70360.
2
The necroptosis-related signature and tumor microenvironment immune characteristics associated with clinical prognosis and drug sensitivity analysis in stomach adenocarcinoma.与胃腺癌临床预后及药物敏感性分析相关的坏死性凋亡相关特征及肿瘤微环境免疫特征
Aging (Albany NY). 2024 Mar 27;16(7):6098-6117. doi: 10.18632/aging.205690.
3
Unveiling a novel model of cell senescence-related genes for prognostic assessment and immunotherapeutic insights in gastric cancer.揭示一种用于胃癌预后评估和免疫治疗见解的细胞衰老相关基因新模型。
Sci Rep. 2025 Feb 12;15(1):5251. doi: 10.1038/s41598-025-89369-3.
4
Prognostic prediction and immune infiltration analysis based on lysosome and senescence state identifies MMP12 as a novel therapy target in gastric cancer.基于溶酶体和衰老状态的预后预测和免疫浸润分析鉴定 MMP12 为胃癌的一个新的治疗靶点。
Int Immunopharmacol. 2024 Dec 25;143(Pt 1):113344. doi: 10.1016/j.intimp.2024.113344. Epub 2024 Oct 13.
5
Immune Infiltration Subtypes Characterization and Identification of Prognosis-Related lncRNAs in Adenocarcinoma of the Esophagogastric Junction.免疫浸润亚型特征分析和胃食管结合部腺癌预后相关长链非编码 RNA 的鉴定。
Front Immunol. 2021 May 28;12:651056. doi: 10.3389/fimmu.2021.651056. eCollection 2021.
6
Identification of a 14-lncRNA Signature and Construction of a Prognostic Nomogram Predicting Overall Survival of Gastric Cancer.鉴定 14 个长链非编码 RNA 标志物并构建预测胃癌总生存期的预后列线图
DNA Cell Biol. 2020 Sep;39(9):1532-1544. doi: 10.1089/dna.2020.5565. Epub 2020 Jul 9.
7
Characterization of the Prognosis and Tumor Microenvironment of Cellular Senescence-related Genes through scRNA-seq and Bulk RNA-seq Analysis in GC.通过 scRNA-seq 和 GC 中 Bulk RNA-seq 分析对细胞衰老相关基因的预后和肿瘤微环境进行特征分析。
Recent Pat Anticancer Drug Discov. 2024;19(4):530-542. doi: 10.2174/0115748928255417230924191157.
8
A novel endoplasmic reticulum stress-related lncRNA signature for prognosis prediction and immune response evaluation in Stomach adenocarcinoma.一个新的与内质网应激相关的 lncRNA 标志物，用于预测胃腺癌的预后和免疫反应评估。
BMC Gastroenterol. 2023 Dec 9;23(1):432. doi: 10.1186/s12876-023-03001-0.
9
Angiogenesis-related lncRNAs predict the prognosis signature of stomach adenocarcinoma.血管生成相关长链非编码 RNA 预测胃腺癌的预后特征。
BMC Cancer. 2021 Dec 7;21(1):1312. doi: 10.1186/s12885-021-08987-y.
10
Development and experimental validation of a senescence-related long non-coding RNA signature for prognostic prediction and immune microenvironment characterization in gastric cancer patients.用于胃癌患者预后预测和免疫微环境特征分析的衰老相关长链非编码RNA特征的开发与实验验证
J Gastrointest Oncol. 2024 Dec 31;15(6):2413-2436. doi: 10.21037/jgo-24-792. Epub 2024 Dec 26.

引用本文的文献

1
Cellular senescence in cancer: from mechanism paradoxes to precision therapeutics.癌症中的细胞衰老：从机制悖论到精准治疗
Mol Cancer. 2025 Aug 8;24(1):213. doi: 10.1186/s12943-025-02419-2.

本文引用的文献

1
Sialylation-associated long non-coding RNA signature predicts the prognosis, tumor microenvironment, and immunotherapy and chemotherapy options in uterine corpus endometrial carcinoma.唾液酸化相关长链非编码RNA特征预测子宫内膜癌的预后、肿瘤微环境以及免疫治疗和化疗选择。
Cancer Cell Int. 2024 Sep 11;24(1):314. doi: 10.1186/s12935-024-03486-z.
2
LINC01579-204 involved in the development of Hirschsprung's disease maybe by regulating the expression of miR-203a-3p and NEFL.LINC01579-204 可能通过调节 miR-203a-3p 和 NEFL 的表达参与先天性巨结肠的发生。
Clin Res Hepatol Gastroenterol. 2023 Dec;47(10):102240. doi: 10.1016/j.clinre.2023.102240. Epub 2023 Nov 2.
3
Mutation-derived, genomic instability-associated lncRNAs are prognostic markers in gliomas.
突变衍生的、与基因组不稳定性相关的长非编码 RNA 是胶质瘤的预后标志物。
PeerJ. 2023 Aug 2;11:e15810. doi: 10.7717/peerj.15810. eCollection 2023.
4
Hyper-methylation of ABCG1 as an epigenetics biomarker in non-small cell lung cancer.ABCG1 高甲基化作为非小细胞肺癌的表观遗传学标志物。
Funct Integr Genomics. 2023 Jul 31;23(3):256. doi: 10.1007/s10142-023-01185-y.
5
Identification and analysis of cellular senescence-associated signatures in diabetic kidney disease by integrated bioinformatics analysis and machine learning.通过整合生物信息学分析和机器学习鉴定和分析糖尿病肾病中的细胞衰老相关特征。
Front Endocrinol (Lausanne). 2023 Jun 16;14:1193228. doi: 10.3389/fendo.2023.1193228. eCollection 2023.
6
Elastic Net Regularization Paths for All Generalized Linear Models.所有广义线性模型的弹性网络正则化路径
J Stat Softw. 2023;106. doi: 10.18637/jss.v106.i01. Epub 2023 Mar 23.
7
Identification and validation of a novel angiogenesis-related gene signature for predicting prognosis in gastric adenocarcinoma.一种用于预测胃腺癌预后的新型血管生成相关基因特征的鉴定与验证
Front Oncol. 2023 Jan 16;12:965102. doi: 10.3389/fonc.2022.965102. eCollection 2022.
8
Blocking PD-L1-PD-1 improves senescence surveillance and ageing phenotypes.阻断 PD-L1-PD-1 可改善衰老监控和衰老表型。
Nature. 2022 Nov;611(7935):358-364. doi: 10.1038/s41586-022-05388-4. Epub 2022 Nov 2.
9
Upregulation of PD-L1 in Senescence and Aging.PD-L1 在衰老和老化中的上调。
Mol Cell Biol. 2022 Oct 20;42(10):e0017122. doi: 10.1128/mcb.00171-22. Epub 2022 Sep 26.
10
Senescence and cancer - role and therapeutic opportunities.衰老与癌症——作用与治疗机遇。
Nat Rev Clin Oncol. 2022 Oct;19(10):619-636. doi: 10.1038/s41571-022-00668-4. Epub 2022 Aug 31.