来自海洋来源链霉菌物种的芳香聚酮化合物。
Aromatic Polyketides From a Marine-Derived Streptomyces Species.
作者信息
Shen Jingjing, Cheng Shan, Liu Zhi, Zhu Weiming, Fu Peng
机构信息
Key Laboratory of Marine Drugs, Ministry of Education of China, School of Medicine and Pharmacy, Ocean University of China, Qingdao, China.
Laboratory for Marine Drugs and Bioproducts, Qingdao Marine Science and Technology Center, Qingdao, China.
出版信息
Chem Biodivers. 2025 Jun;22(6):e202500129. doi: 10.1002/cbdv.202500129. Epub 2025 Feb 4.
Three new naphthalene derivatives, strepthalenes A-C (1-3), and the known analogue (S)-DNPA (4), together with six previously reported anthraquinones (5-10), were isolated from the marine-derived Streptomyces sp. OUCMDZ-4182. Their structures were elucidated by detailed spectroscopic analysis and quantum chemical calculations. Strepthalenes B and C showed moderate activity against amyloid-β 42 (Aβ42) aggregation with IC values of 47.65 and 24.73 µM, respectively.
从海洋来源的链霉菌OUCMDZ-4182中分离出三种新的萘衍生物，即链霉菌素A-C（1-3）、已知类似物（S）-DNPA（4），以及六种先前报道的蒽醌（5-10）。通过详细的光谱分析和量子化学计算确定了它们的结构。链霉菌素B和C对淀粉样β-蛋白42（Aβ42）聚集表现出中等活性，其半数抑制浓度（IC）值分别为47.65和24.73 μM。
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