来自一种海洋藻类衍生物种的芳香聚酮化合物和异羟肟酸铁载体

Aromatic Polyketides and Hydroxamate Siderophores from a Marine-Algae-Derived Species.

作者信息

Xia Kunyu, Luo Hui, Ma Rui, Zhang Rongxin, Zhu Weiming, Fu Peng

机构信息

Key Laboratory of Marine Drugs, Ministry of Education of China, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, People's Republic of China.

Laboratory for Marine Drugs and Bioproducts, Pilot National Laboratory for Marine Science and Technology (Qingdao), Qingdao 266237, People's Republic of China.

出版信息

J Nat Prod. 2021 May 28;84(5):1550-1555. doi: 10.1021/acs.jnatprod.1c00061. Epub 2021 May 13.

DOI:10.1021/acs.jnatprod.1c00061

PMID:33983744

Abstract

Four new aromatic polyketides, wailupemycins M-P (-), and two new hydroxamate siderophores, streptamides A () and B (), together with the previously reported nocardamine (), were isolated from the marine-algae-derived sp. OUCMDZ-3434. Wailupemycins M-P (-), possessing an α-pyrone moiety, were isolated from the extract of a liquid fermentation, and the siderophores (-) were isolated from the extract of a solid fermentation. Their structures were assigned based on detailed spectroscopic analysis and quantum chemical calculations. Compounds - were capable of binding Fe(III). Compound can form a tighter Fe(III) complex than that of deferoxamine B mesylate (DFB).

摘要

从源自海洋藻类的链霉菌属OUCMDZ - 3434中分离出四种新的芳香族聚酮化合物，威鲁培霉素M - P（-），以及两种新的异羟肟酸铁载体，链霉酰胺A（）和B（），同时还分离出了先前报道的诺卡胺（）。具有α - 吡喃酮部分的威鲁培霉素M - P（-）是从液体发酵提取物中分离得到的，而铁载体（-）则是从固体发酵提取物中分离得到的。它们的结构是基于详细的光谱分析和量子化学计算确定的。化合物 - 能够结合Fe(III)。化合物比甲磺酸去铁胺B（DFB）能形成更紧密的Fe(III)络合物。