Takebe H
Gan To Kagaku Ryoho. 1985 Mar;12(3 Pt 2):589-94.
Since the discovery of a DNA repair defect in xeroderma pigmentosum, which had been known as a hereditary cancer-prone disease, the presence of a genetically high risk group for cancer has been clearly recognized. Clinical and cellular investigations on xeroderma pigmentosum patients in Japan in comparison with those carried out in the United States and Europe have revealed that the characteristics of Japanese patients are considerably different from those in other countries. Similar differences have been noted in other related diseases like Bloom's syndrome. These results suggested that each ethnic group might have unique features with regard to the genetic background of carcinogenesis. Our research over the last 10 years has always been in good collaboration with colleagues in the USA, Europe and Korea thanks to support from the Japan Society for the Promotion of Sciences and the US-Japan Cooperative Medical Science Program, which has enabled us to perform comparative experimental work in foreign countries and to standardize methods and evaluation criteria.
自从在色素性干皮病（一种已知的遗传性易患癌症疾病）中发现DNA修复缺陷以来，癌症遗传高危人群的存在已得到明确认可。对日本色素性干皮病患者进行的临床和细胞研究与在美国和欧洲进行的研究相比，发现日本患者的特征与其他国家的患者有很大不同。在其他相关疾病如布卢姆综合征中也注意到了类似的差异。这些结果表明，每个种族群体在致癌的遗传背景方面可能具有独特的特征。在日本科学促进会和美日合作医学科学项目的支持下，我们在过去10年里一直与美国、欧洲和韩国的同事保持良好合作，这使我们能够在国外开展比较实验工作，并使方法和评估标准标准化。
