Bikbov Mukharram M, Kazakbaeva Gyulli M, Rakhimova Ellina M, Panda-Jonas Songhomitra, Tuliakova Azaliia M, Fakhretdinova Albina A, Jonas Jost B
Ufa Eye Research Institute of Bashkir State Medical University, Ufa, Russia.
Privatpraxis Prof Jonas und Dr Panda-Jonas, Heidelberg, Germany.
Eye (Lond). 2025 May;39(7):1322-1331. doi: 10.1038/s41433-025-03615-6. Epub 2025 Jan 24.
To assess associations between mortality and major ocular parameters and diseases.
The population-based Ural Eye and Medical Study (UEMS) and Ural Very Old Study (UVOS) included 5899 individuals (age: 40+ years) and 1526 individuals (age: 85+ years), respectively. Cause-specific mortality was determined using the government regional information and analytical system.
In the UEMS, 689 (11.7%) participants had died during the follow-up of 7.0 ± 0.4 years (median: 6.9 years). Higher death occurrence was associated (multivariable analysis) with lower best corrected visual acuity (OR: 1.86; 95%CI:1.10, 2.68) and higher prevalence of diabetic retinopathy (OR: 2.97; 95%CI: 1.68, 5.26), with adjusting for older age (OR: 1.08), male sex (OR: 4.18), higher waist-hip ratio (OR: 5.53), current smoking (OR: 2.25), history of cancer (OR: 1.93) and dementia (OR: 2.54), higher serum concentration of glucose (OR: 1.13) and lower serum concentration of high-density lipoproteins (OR: 0.89) and haemoglobin (OR: 0.99), higher leucocyte count (OR: 1.07), higher prevalence of chronic obstructive pulmonary disease (OR: 1.67), higher stage of arterial hypertension (OR: 1.15), and higher depression score (OR: 1.04). Death occurrence was not significantly associated with prevalence of age-related macular degeneration (P = 0.90), macular reticular pseudodrusen (P = 0.90), open-angle glaucoma (P = 0.11), angle-closure glaucoma (P = 0.98), nuclear cataract (P = 0.07), cortical cataract (P = 0.46), axial length (P = 0.44) and intraocular pressure (P = 0.87). In the UVOS, 791 (51.9%) participants had died during the follow-up of 4.8 ± 1.0 years (median: 5.2 years). None of the ophthalmological parameters was significantly associated with death occurrence.
Diabetic retinopathy was the only major ophthalmic disease or parameter, in addition to vision impairment, which was associated with an increased death risk.
评估死亡率与主要眼部参数及疾病之间的关联。
基于人群的乌拉尔眼与医学研究（UEMS）和乌拉尔高龄研究（UVOS）分别纳入了5899名个体（年龄：40岁及以上）和1526名个体（年龄：85岁及以上）。使用政府区域信息和分析系统确定特定病因死亡率。
在UEMS中，689名（11.7%）参与者在7.0±0.4年（中位数：6.9年）的随访期间死亡。较高的死亡发生率与较低的最佳矫正视力相关（多变量分析，OR：1.86；95%CI：1.10，2.68）以及糖尿病视网膜病变的较高患病率相关（OR：2.97；95%CI：1.68，5.26），并对年龄较大（OR：1.08）、男性（OR：4.18）、较高的腰臀比（OR：5.53）、当前吸烟（OR：2.25）、癌症病史（OR：1.93）和痴呆病史（OR：2.54）、较高的血清葡萄糖浓度（OR：1.13）以及较低的血清高密度脂蛋白浓度（OR：0.89）和血红蛋白（OR：0.99）、较高的白细胞计数（OR：1.07）、慢性阻塞性肺疾病的较高患病率（OR：1.67）、动脉高血压的较高分期（OR：1.15）和较高的抑郁评分（OR：1.04）进行了校正。死亡发生率与年龄相关性黄斑变性的患病率（P = 0.90）、黄斑网状假性玻璃膜疣（P = 0.90）、开角型青光眼（P = 0.11）、闭角型青光眼（P = 0.98）、核性白内障（P = 0.07）、皮质性白内障（P = 0.46）、眼轴长度（P = 0.44）和眼压（P = 0.87）无显著关联。在UVOS中，791名（51.9%）参与者在4.8±1.0年（中位数：5.2年）的随访期间死亡。没有眼科参数与死亡发生率显著相关。
除视力损害外，糖尿病视网膜病变是唯一与死亡风险增加相关的主要眼科疾病或参数。
