Chen Qian, Elwood Mark, Campbell Ian, Cavadino Alana, Aye Phyu Sin, Tin Tin Sandar
Department of Epidemiology and Biostatistics, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand.
Department of Surgery, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand.
Breast Cancer Res Treat. 2025 Apr;210(2):439-449. doi: 10.1007/s10549-024-07582-6. Epub 2025 Jan 25.
In New Zealand, BreastScreen Aotearoa (BSA), a biennial national breast screening programme, was implemented in 1998. This study examines the incidence trends of ductal carcinoma in situ (DCIS) in New Zealand women from 1999 to 2022.
All women with a primary diagnosis of DCIS over the 24-year study period were identified from the New Zealand Cancer Registry and BSA records. Age-standardised incidence rates (ASIR), detection rates (ASDR) and average annual percent changes were calculated.
The annual ASIR was 13.5 per 100,000 New Zealand women, and increased by 0.91% (95% confidence interval (CI): 0.26%, 1.66%) annually. Among women aged 45-69 years during 2006-2022, the annual ASIR was 36.3 for programme-detected DCIS, increasing 1.29% (95%CI: 0.13%, 2.73%) per year, and 14.2 for non-programme-detected DCIS, with no significant changes over the study period. The programme-detected ASIRs were highest for Pacific (38.6), Asian (38.2), and Māori (38.0) women. The programme ASDR was 0.55 per 1000 women screened, with no significant changes over time, and was highest for Asian (0.69), and Māori and Pacific (both at 0.65) women.
DCIS incidence increased in New Zealand women from 1999 to 2022, driven by an increase in screening participation, and varied by ethnicity.
在新西兰，全国性的两年一次乳房筛查项目“新西兰乳房筛查”（BreastScreen Aotearoa，BSA）于1998年实施。本研究调查了1999年至2022年新西兰女性原位导管癌（DCIS）的发病趋势。
从新西兰癌症登记处和BSA记录中识别出在24年研究期间初次诊断为DCIS的所有女性。计算年龄标准化发病率（ASIR）、检出率（ASDR）和年均变化百分比。
新西兰女性的年ASIR为每10万人13.5例，且每年增加0.91%（95%置信区间（CI）：0.26%，1.66%）。在2006 - 2022年期间，45 - 69岁的女性中，筛查发现的DCIS年ASIR为36.3例，每年增加1.29%（95%CI：0.13%，2.73%），非筛查发现的DCIS为14.2例，在研究期间无显著变化。筛查发现的ASIR在太平洋岛民（38.6）、亚洲（38.2）和毛利（38.0）女性中最高。筛查项目的ASDR为每1000名接受筛查的女性0.55例，随时间无显著变化，在亚洲女性（0.69）以及毛利和太平洋岛民女性（均为0.65）中最高。
从1999年到2022年，新西兰女性DCIS发病率上升，这是由于筛查参与率增加所致，且存在种族差异。
