调用你的标志物：生物标志物能否预测克罗恩病患儿对抗肿瘤坏死因子治疗的反应？ - Suppr

Calling in Your Markers: Can Biomarkers Predict the Response to Anti-TNF Therapy in Pediatric Patients with Crohn's Disease?

作者信息

Watson Kevin L

机构信息

Division of Pediatric Gastroenterology, Hepatology and Nutrition, Akron Children's Hospital, 215 W Bowery Street, 6th floor, Akron, OH, 44308, USA.

出版信息

Dig Dis Sci. 2025 Mar;70(3):888-889. doi: 10.1007/s10620-025-08856-9. Epub 2025 Jan 24.

DOI:10.1007/s10620-025-08856-9

PMID:39856482

Abstract

摘要

相似文献

Calling in Your Markers: Can Biomarkers Predict the Response to Anti-TNF Therapy in Pediatric Patients with Crohn's Disease?调用你的标志物：生物标志物能否预测克罗恩病患儿对抗肿瘤坏死因子治疗的反应？

Dig Dis Sci. 2025 Mar;70(3):888-889. doi: 10.1007/s10620-025-08856-9. Epub 2025 Jan 24.

[Anti-TNF therapy in treatment of luminal Crohn's disease].[抗TNF治疗在腔内型克罗恩病治疗中的应用]

Acta Med Croatica. 2013 Apr;67(2):179-89.

Mechanisms and management of loss of response to anti-TNF therapy for patients with Crohn's disease: 3-year data from the prospective, multicentre PANTS cohort study.抗 TNF 治疗克罗恩病患者应答丧失的机制和管理：前瞻性、多中心 PANTS 队列研究的 3 年数据。

Lancet Gastroenterol Hepatol. 2024 Jun;9(6):521-538. doi: 10.1016/S2468-1253(24)00044-X. Epub 2024 Apr 16.

Predictors of anti-TNF treatment failure in anti-TNF-naive patients with active luminal Crohn's disease: a prospective, multicentre, cohort study.抗 TNF 初治活动期腔型克罗恩病患者抗 TNF 治疗失败的预测因素：一项前瞻性、多中心、队列研究。

Lancet Gastroenterol Hepatol. 2019 May;4(5):341-353. doi: 10.1016/S2468-1253(19)30012-3. Epub 2019 Feb 27.

Metabonomics and the Gut Microbiome Associated With Primary Response to Anti-TNF Therapy in Crohn's Disease.代谢组学和肠道微生物群与克罗恩病对 TNF 治疗的原发性反应相关。

J Crohns Colitis. 2020 Sep 7;14(8):1090-1102. doi: 10.1093/ecco-jcc/jjaa039.

Tumor necrosis factor-alpha antibody for maintenance of remission in Crohn's disease.用于维持克罗恩病缓解的肿瘤坏死因子-α抗体。

Cochrane Database Syst Rev. 2008 Jan 23(1):CD006893. doi: 10.1002/14651858.CD006893.

Comparative effectiveness of ustekinumab or vedolizumab after one year in 130 patients with anti-TNF-refractory Crohn's disease.130 例抗 TNF 治疗失败的克罗恩病患者中乌司奴单抗或维得利珠单抗治疗 1 年后的疗效比较。

Aliment Pharmacol Ther. 2020 Oct;52(8):1341-1352. doi: 10.1111/apt.16057. Epub 2020 Sep 10.

Prediction of deep remission through serum TNF-α level at 1 year of treatment in pediatric Crohn's disease.通过儿童克罗恩病治疗1年时的血清肿瘤坏死因子-α水平预测深度缓解

Sci Rep. 2025 Apr 1;15(1):5770. doi: 10.1038/s41598-025-89578-w.

Serological Biomarkers of Tissue Turnover Identify Responders to Anti-TNF Therapy in Crohn's Disease: A Pilot Study.血清学组织转换标志物可识别克罗恩病抗 TNF 治疗的应答者：一项初步研究。

Clin Transl Gastroenterol. 2020 Sep;11(9):e00217. doi: 10.14309/ctg.0000000000000217.

Concomitant therapy with methotrexate and anti-TNF-α in pediatric patients with refractory crohn's colitis: a case series.在难治性克罗恩病患儿中联合使用甲氨蝶呤和抗 TNF-α 治疗：病例系列研究。

Inflamm Bowel Dis. 2012 Aug;18(8):1488-92. doi: 10.1002/ibd.21885. Epub 2011 Aug 31.

引用本文的文献

The importance of ALPK1 kinase functionality as a potential biomarker for inflammatory diseases.ALPK1激酶功能作为炎症性疾病潜在生物标志物的重要性。

Mol Biol Rep. 2025 Jun 10;52(1):575. doi: 10.1007/s11033-025-10528-w.

本文引用的文献

Serological Markers as Predictors of Anti-TNF Response in Children with Crohn's Disease.血清学标志物作为克罗恩病患儿抗TNF反应的预测指标

Dig Dis Sci. 2025 Jan;70(1):333-339. doi: 10.1007/s10620-024-08732-y. Epub 2024 Nov 27.

Durability of Adalimumab and Infliximab in Children With Crohn's Disease: A Nationwide Comparison From the epi-IIRN Cohort.阿达木单抗和英夫利昔单抗治疗儿童克罗恩病的持久性：来自 epi-IIRN 队列的全国性比较。

Inflamm Bowel Dis. 2024 Nov 4;30(11):2097-2104. doi: 10.1093/ibd/izad301.

Long-term effectiveness and safety of anti-TNF in pediatric-onset inflammatory bowel diseases: A population-based study.抗 TNF 在儿童发病炎症性肠病中的长期疗效和安全性：一项基于人群的研究。

Dig Liver Dis. 2024 Jan;56(1):21-28. doi: 10.1016/j.dld.2023.04.017. Epub 2023 May 1.

Clin Transl Gastroenterol. 2020 Sep;11(9):e00217. doi: 10.14309/ctg.0000000000000217.

Effect of a Practice-wide Anti-TNF Proactive Therapeutic Drug Monitoring Program on Outcomes in Pediatric Patients with Inflammatory Bowel Disease.全实践范围抗 TNF 主动治疗药物监测方案对炎症性肠病儿科患者结局的影响。

Inflamm Bowel Dis. 2021 Mar 15;27(4):482-492. doi: 10.1093/ibd/izaa102.

Increased prevalence of anti-TNF therapy in paediatric inflammatory bowel disease is associated with a decline in surgical resections during childhood.在儿科炎症性肠病中，抗 TNF 治疗的患病率增加与儿童时期手术切除率的下降有关。

Aliment Pharmacol Ther. 2019 Feb;49(4):398-407. doi: 10.1111/apt.15094. Epub 2019 Jan 9.

Safety and efficacy of adalimumab for moderate to severe Crohn's disease in children.阿达木单抗治疗儿童中重度克罗恩病的安全性和有效性。

Gastroenterology. 2012 Aug;143(2):365-74.e2. doi: 10.1053/j.gastro.2012.04.046. Epub 2012 May 2.

Long-term outcome of tumor necrosis factor alpha antagonist's treatment in pediatric Crohn's disease.肿瘤坏死因子-α拮抗剂治疗小儿克罗恩病的长期疗效。

J Crohns Colitis. 2013 Jun;7(5):369-76. doi: 10.1016/j.crohns.2012.03.006. Epub 2012 Apr 5.

Induction and maintenance infliximab therapy for the treatment of moderate-to-severe Crohn's disease in children.英夫利昔单抗诱导和维持治疗儿童中重度克罗恩病

Gastroenterology. 2007 Mar;132(3):863-73; quiz 1165-6. doi: 10.1053/j.gastro.2006.12.003. Epub 2006 Dec 3.

Serological markers for prediction of response to anti-tumor necrosis factor treatment in Crohn's disease.用于预测克罗恩病患者对抗肿瘤坏死因子治疗反应的血清学标志物

Am J Gastroenterol. 2002 Jun;97(6):1458-62. doi: 10.1111/j.1572-0241.2002.05689.x.

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Calling in Your Markers: Can Biomarkers Predict the Response to Anti-TNF Therapy in Pediatric Patients with Crohn's Disease?

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