患有或未患有对立违抗障碍的多动症儿童杏仁核各亚区域的功能和结构连通性。
Functional and structural connectivity of the subregions of the amygdala in ADHD children with or without ODD.
作者信息
Wu Zhao-Min, Wang Peng, Liu Xue-Chun, Zhou Qing-Chao, Cao Xiao-Lan, Sun Li, Liu Lu, Cao Qing-Jiu, Yang Li, Wang Yu-Feng, Qian Ying, Yang Bin-Rang
机构信息
Shenzhen Children's Hospital, Shenzhen, 518000, China.
Affiliated Shenzhen Children's Hospital of Shantou University Medical College, Shenzhen, 518000, China.
出版信息
BMC Psychiatry. 2025 Jan 24;25(1):74. doi: 10.1186/s12888-025-06500-4.
OBJECTIVES
The current study aimed to investigate the structural and functional connectivity of the subregions of the amygdala in children with Attention Deficit/Hyperactivity Disorder (ADHD) only or comorbid with Oppositional Defiant Disorder (ODD).
METHODS
A total of 354 children with ADHD-only, 161 children with ADHD and ODD (ADHD + ODD), and 100 healthy controls were enrolled. The Child Behavior Checklist (CBCL) and the Behavior Rating Inventory of Executive Function (BRIEF) were filled out by caregivers. Analysis of covariance (ANCOVA) was performed to test group-wise differences in these behavioral measures. A subsample comprising 209 participants underwent a resting-state functional MRI scan and a diffusion-weighted imaging (DWI) scan. Functional connectivity and structural connectivity were calculated using bilateral subregions of the Amygdala as seeds. Between-group voxel-wise comparisons were conducted.
RESULTS
The ADHD + ODD group had more anxious/depressed moods, more delinquent and aggressive behaviors, more emotional control problems, and more inhibition deficits than the ADHD-only group (all P < 0.05). Compared with the control and ADHD + ODD groups, the ADHD-only group displayed increased FC strength between the amygdala subregions and the left caudate, left putamen, and frontal cortex. Regarding structural connectivity (SC), the ADHD-only group demonstrated higher streamline density in the left internal capsule, corpus callosum, and the right superior corona radiata. The altered SC was associated with emotional problems in children with ADHD, while the altered FC was associated with other ADHD-related clinical features.
CONCLUSIONS
Altered structural and functional connectivity of the subregions of the amygdala in children with ADHD compared with their healthy counterparts were respectively associated with ADHD-related behavioral and emotional problems.
CLINICAL TRIAL NUMBER
not applicable.
目的
本研究旨在调查仅患有注意力缺陷多动障碍（ADHD）或合并对立违抗障碍（ODD）的儿童杏仁核各亚区域的结构和功能连接性。
方法
共招募了354名仅患有ADHD的儿童、161名患有ADHD和ODD（ADHD+ODD）的儿童以及100名健康对照。照顾者填写了儿童行为检查表（CBCL）和执行功能行为评定量表（BRIEF）。进行协方差分析（ANCOVA）以检验这些行为指标在组间的差异。一个由209名参与者组成的子样本接受了静息态功能磁共振成像扫描和扩散加权成像（DWI）扫描。以杏仁核的双侧亚区域为种子计算功能连接性和结构连接性。进行了组间体素水平的比较。
结果
与仅患有ADHD的组相比，ADHD+ODD组有更多的焦虑/抑郁情绪、更多的违法和攻击行为、更多的情绪控制问题以及更多的抑制缺陷（所有P<0.05）。与对照组和ADHD+ODD组相比，仅患有ADHD的组在杏仁核亚区域与左侧尾状核、左侧壳核和额叶皮质之间显示出增强的功能连接强度。关于结构连接性（SC），仅患有ADHD的组在左侧内囊、胼胝体和右侧放射冠上部表现出更高的纤维束密度。改变的SC与ADHD儿童的情绪问题相关，而改变的FC与其他ADHD相关的临床特征相关。
结论
与健康儿童相比，ADHD儿童杏仁核亚区域的结构和功能连接性改变分别与ADHD相关的行为和情绪问题有关。
临床试验编号
不适用。
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