Jeong Byeong-Ho, Ho Rong Lih, Lee Ho Yun, Han Joungho, Kim Hojoong
Division of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul, 06351, Republic of Korea.
Department of Respiratory, Queen Elizabeth Hospital, Sabah, Malaysia.
BMC Pulm Med. 2025 Jan 24;25(1):37. doi: 10.1186/s12890-025-03476-5.
Pulmonary inflammatory myofibroblastic tumor (IMT) accounts for 0.04-0.7% of all lung tumors, and endobronchial IMT accounts for only 10% of all pulmonary IMTs. Little is known about the therapeutic outcomes of rigid bronchoscopy for endobronchial IMT. Here, we report a case series of eight patients with endobronchial IMT underwent rigid bronchoscopy.
We retrospectively analyzed eight patients with endobronchial IMT between January 2004 and December 2023.
The median age of our patients was 36 years, and 62.5% were male. Dyspnea was the predominant symptom in cases where the tumor was centrally located (n = 6), whereas hemoptysis was the predominant symptom in peripherally located tumors (n = 2). Most cases had high contrast enhancement and a tumor stalk without bronchial wall invasion on computed tomography (CT) and bronchoscopy. Complete endoscopic resection and laser cauterization via rigid bronchoscopy were possible in five patients. There were only two cases in which tumors remained after the procedure, requiring additional treatment (chemotherapy and surgical resection, respectively). In one patient, surgical resection was performed three weeks after the procedure, and the surgical specimen was free of residual tumor. There was no mortality during the median follow-up duration of 18.8 months.
Endoscopic resection and laser cauterization using rigid bronchoscopy may serve as a safe and effective alternative treatment modality to surgery for patients with endobronchial IMT.
肺炎症性肌纤维母细胞瘤（IMT）占所有肺部肿瘤的0.04 - 0.7%，而支气管内IMT仅占所有肺IMT的10%。关于硬质支气管镜治疗支气管内IMT的治疗效果知之甚少。在此，我们报告一组8例接受硬质支气管镜检查的支气管内IMT患者的病例系列。
我们回顾性分析了2004年1月至2023年12月期间的8例支气管内IMT患者。
我们患者的中位年龄为36岁，62.5%为男性。呼吸困难是肿瘤位于中央的病例（n = 6）的主要症状，而咯血是肿瘤位于周边的病例（n = 2）的主要症状。大多数病例在计算机断层扫描（CT）和支气管镜检查中具有高对比度增强且有肿瘤蒂，无支气管壁侵犯。5例患者通过硬质支气管镜进行了完整的内镜切除和激光烧灼。术后仅2例肿瘤残留，分别需要额外治疗（化疗和手术切除）。1例患者在术后3周进行了手术切除，手术标本无残留肿瘤。在18.8个月的中位随访期内无死亡病例。
对于支气管内IMT患者，使用硬质支气管镜进行内镜切除和激光烧灼可能是一种安全有效的替代手术的治疗方式。
