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优诺思强效片(替马西泮)治疗难治性失眠:一项临床试验。

Euhypnos Forte (temazepam) for resistant insomnia: a clinical trial.

作者信息

Moon C A, Schiller M

出版信息

J Int Med Res. 1979;7(4):295-301. doi: 10.1177/030006057900700407.

Abstract

Seventy insomniac patients, previously unresponsive to conventional hypnotic dosage, were treated for seven nights with temazepam in 20 mg soft gelatin capsules (Euhypnos Forte). The patients adjusted the dose to suit themselves up to a maximum of 60 mg. Nineteen patients found that one 20 mg capsule suited them best in spite of previous lack of response to two 10 mg capsules, and were thus excluded from the final analysis. Out of the remaining fifty-one patients, thirty-five were best suited by 40 mg and sixteen by 60 mg of temazepam. Sleep was rated Very Good or Good by forty patients (78.4%) and significant hangover occurred in only four (7.8%), all of whom were on 40 mg. Adverse reactions were insignificant. Some observations by one author (CALM) on the significance of the results in the management of insomnia in general practice are included.

摘要

70名此前对常规催眠剂量无反应的失眠患者,连续7晚服用20毫克软胶囊剂型的替马西泮(优眠宁长效胶囊)进行治疗。患者自行调整剂量,最大剂量为60毫克。19名患者发现一粒20毫克胶囊最适合他们,尽管之前服用两粒10毫克胶囊时并无反应,因此这19名患者被排除在最终分析之外。在其余51名患者中,35名患者服用40毫克替马西泮效果最佳,16名患者服用60毫克效果最佳。40名患者(78.4%)将睡眠评为“非常好”或“好”,只有4名患者(7.8%)出现明显宿醉,这4名患者均服用40毫克剂量。不良反应不明显。本文还收录了一位作者(CALM)对这些结果在全科医疗中治疗失眠的意义的一些观察。

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