替马西泮的催眠疗效：一项长期睡眠实验室评估。
Hypnotic efficacy of temazepam: a long-term sleep laboratory evaluation.
作者信息
Mitler M M, Carskadon M A, Phillips R L, Sterling W R, Zarcone V P, Spiegel R, Guilleminault C, Dement W C
出版信息
Br J Clin Pharmacol. 1979;8(1):63S-68S. doi: 10.1111/j.1365-2125.1979.tb00459.x.
Abstract
1 Temazepam was evaluated in a strictly defined insomniac patient population under sleep laboratory conditions. Two protocols were used: a short-term (26-night) and a long-term (54-night) protocol evaluated the efficacy of the drug administered at night at 15 mg (short-term study) and 30 mg (long-term study), respectively. 2 Temazepam seemed to be both safe and effective at doses of 15 and 30 mg with up to 5 weeks of ingestion. 3 Suppression of slow wave sleep was observed at the high dose, but no suppression of REM sleep, found in studies with other benzodiazepines, was noted. 4 No evidence was found for development of tolerance or rebound effects.
摘要
- 在睡眠实验室条件下，对严格界定的失眠患者群体进行了替马西泮评估。采用了两种方案：短期（26晚）和长期（54晚）方案，分别评估了夜间服用15毫克（短期研究）和30毫克（长期研究）药物的疗效。2. 替马西泮在15毫克和30毫克剂量下，服用长达5周时似乎既安全又有效。3. 在高剂量时观察到慢波睡眠受到抑制，但未发现其他苯二氮䓬类药物研究中出现的快速眼动睡眠抑制现象。4. 未发现耐受性或反跳效应产生的证据。
相似文献
1
Hypnotic efficacy of temazepam: a long-term sleep laboratory evaluation.替马西泮的催眠疗效：一项长期睡眠实验室评估。
Br J Clin Pharmacol. 1979;8(1):63S-68S. doi: 10.1111/j.1365-2125.1979.tb00459.x.
2
Quazepam and temazepam: effects of short- and intermediate-term use and withdrawal.夸西泮和替马西泮：短期及中期使用与戒断的影响
Clin Pharmacol Ther. 1986 Mar;39(3):345-52. doi: 10.1038/clpt.1986.51.
3
Sleep laboratory studies of hypnotic drugs: efficacy and withdrawal effects.催眠药物的睡眠实验室研究：疗效与戒断效应
J Clin Psychopharmacol. 1983 Apr;3(2):140-50. doi: 10.1097/00004714-198304000-00038.
4
The effects of midazolam and temazepam on sleep and performance when administered in the middle of the night.咪达唑仑和替马西泮在午夜给药时对睡眠和行为表现的影响。
J Clin Psychopharmacol. 1985 Apr;5(2):66-9. doi: 10.1097/00004714-198504000-00002.
5
Double-blind evaluation of the safety and hypnotic efficacy of temazepam in insomniac outpatients.替马西泮对失眠门诊患者安全性和催眠疗效的双盲评估。
Br J Clin Pharmacol. 1979;8(1):69S-72S. doi: 10.1111/j.1365-2125.1979.tb00460.x.
6
Psycho-social stress, insomnia and temazepam: a sleep laboratory evaluation in a "general practice" sample.
Psychopharmacology (Berl). 1984;83(1):17-9. doi: 10.1007/BF00427415.
7
Zolpidem is not superior to temazepam with respect to rebound insomnia: a controlled study.唑吡坦在反弹性失眠方面并不优于替马西泮：一项对照研究。
Eur Neuropsychopharmacol. 2004 Aug;14(4):301-6. doi: 10.1016/j.euroneuro.2003.09.007.
8
Evaluation of temazepam as a hypnotic.替马西泮作为催眠药的评估。
Pharmacotherapy. 1981 Jul-Aug;1(1):3-13. doi: 10.1002/j.1875-9114.1981.tb03546.x.
9
Euhypnos Forte (temazepam) for resistant insomnia: a clinical trial.优诺思强效片（替马西泮）治疗难治性失眠：一项临床试验。
J Int Med Res. 1979;7(4):295-301. doi: 10.1177/030006057900700407.
10
Treatment of insomnia with temazepam: double-blind, placebo-controlled evaluation.替马西泮治疗失眠症：双盲、安慰剂对照评估。
Clin Ther. 1982;4(5):402-12.
引用本文的文献
1
Mechanisms Underlying Tolerance after Long-Term Benzodiazepine Use: A Future for Subtype-Selective GABA(A) Receptor Modulators?长期使用苯二氮䓬类药物后耐受性的潜在机制：亚型选择性GABA(A)受体调节剂的未来？
Adv Pharmacol Sci. 2012;2012:416864. doi: 10.1155/2012/416864. Epub 2012 Mar 29.
2
Polysomnographic effects of hypnotic drugs. A review.催眠药物的多导睡眠图效应。综述。
Psychopharmacology (Berl). 1996 Jul;126(1):1-16. doi: 10.1007/BF02246405.
3
Temazepam 7.5 mg: effects on sleep in elderly insomniacs.替马西泮7.5毫克：对老年失眠患者睡眠的影响。
Eur J Clin Pharmacol. 1994;46(3):209-13. doi: 10.1007/BF00192550.
4
Hypnotics: rebound insomnia and residual sequelae.催眠药：反弹性失眠和残留后遗症。
Br J Clin Pharmacol. 1980 Mar;9(3):223-5. doi: 10.1111/j.1365-2125.1980.tb04829.x.
5
Brotizolam: a sleep laboratory evaluation.溴替唑仑：一项睡眠实验室评估。
Eur J Clin Pharmacol. 1983;25(1):53-6. doi: 10.1007/BF00544014.
6
Temazepam's efficacy in patients with sleep onset insomnia.替马西泮对入睡性失眠患者的疗效。
Br J Clin Pharmacol. 1984 Jun;17(6):691-6. doi: 10.1111/j.1365-2125.1984.tb02405.x.
7
Psycho-social stress, insomnia and temazepam: a sleep laboratory evaluation in a "general practice" sample.
Psychopharmacology (Berl). 1984;83(1):17-9. doi: 10.1007/BF00427415.
8
The use of short- and long-acting hypnotics in clinical medicine.短效和长效催眠药在临床医学中的应用。
Br J Clin Pharmacol. 1981;11 Suppl 1(Suppl 1):61S-69S. doi: 10.1111/j.1365-2125.1981.tb01841.x.
9
Model insomnia by methylphenidate and caffeine and use in the evaluation of temazepam.用哌甲酯和咖啡因建立失眠模型并用于替马西泮的评价。
Psychopharmacology (Berl). 1982;76(3):201-8. doi: 10.1007/BF00432545.
10
Temazepam: a review of its pharmacological properties and therapeutic efficacy as an hypnotic.替马西泮：对其作为催眠药的药理特性和治疗效果的综述。
Drugs. 1981 May;21(5):321-40. doi: 10.2165/00003495-198121050-00001.
本文引用的文献
1
Effects of placebo and flurazepam on sleep patterns in insomniac subjects.安慰剂和氟西泮对失眠症患者睡眠模式的影响。
Clin Pharmacol Ther. 1971 Jul-Aug;12(4):691-7. doi: 10.1002/cpt1971124691.
2
Rebound insomnia: a new clinical syndrome.
Science. 1978 Sep 15;201(4360):1039-41. doi: 10.1126/science.684426.
3
Effectiveness of hypnotic drugs with prolonged use: flurazepam and pentobarbital.
Clin Pharmacol Ther. 1975 Sep;18(3):356-63. doi: 10.1002/cpt1975183356.
4
Flurazepam effects on slow-wave sleep: stage 4 suppressed but number of delta waves constant.氟西泮对慢波睡眠的影响：第4期受到抑制，但δ波数量不变。
Science. 1977 Nov 25;198(4319):847-8. doi: 10.1126/science.21453.
Zotero 插件