Keskin Yasemin, Sevinç Hakan, Hazinedaroğlu Selçuk Mevlüt, Morkavuk Şevket Barış, Ersöz Şiyar
Department of General Surgery, Dr. Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital, Ankara 06200, Turkey.
Department of General Surgery, Ankara University School of Medicine, Ankara 06200, Turkey.
Diagnostics (Basel). 2025 Jan 10;15(2):152. doi: 10.3390/diagnostics15020152.
: The aim of the present study was to calculate HALP and modified HALP scores for patients diagnosed with acute cholecystitis (AC) and to determine the predictive utility of these scores for surgical timing and morbidity in patients who underwent surgery for AC. : This study included data from 641 patients who underwent surgery for AC between January 2010 and May 2023. The HALP score was calculated using the formula hemoglobin (g/L) × albumin (g/L) × lymphocyte (10/L)/platelets (10/L). The modified HALP score was calculated using the formula hemoglobin (g/L) × albumin (g/L) × lymphocyte (10/L) × platelets (10/L). : The mean HALP score was 46.81, and the mean modified HALP score was 2,758,401.21. Laparoscopic cholecystectomy (LC) was successfully completed in 582 (90.8%) patients. When examining the relationship between HALP and modified HALP scores and the procedure type, a statistically significant difference was found in the distribution of median HALP and modified HALP scores between the LC and laparoscopic and open cholecystectomy (LTOC) groups. For patients with a HALP score < 34.43 and modified HALP score < 2,077,019, the likelihood of conversion to open surgery increased, with a sensitivity of 65.5% vs. 58.8% and a specificity of 66.1% vs. 59.3%. In patients who underwent surgery, there was a significant difference in the LTOC between the HALP score and modified HALP score cut-off groups ( < 0.001 and, = 0.007). : Evaluation of the HALP score is a promising and valuable assessment method for designing appropriate treatment and management strategies for patients with AC.
本研究的目的是计算诊断为急性胆囊炎（AC）患者的HALP和改良HALP评分，并确定这些评分对接受AC手术患者的手术时机和发病率的预测效用。
本研究纳入了2010年1月至2023年5月期间641例接受AC手术患者的数据。HALP评分采用血红蛋白（g/L）×白蛋白（g/L）×淋巴细胞（10⁹/L）/血小板（10⁹/L）公式计算。改良HALP评分采用血红蛋白（g/L）×白蛋白（g/L）×淋巴细胞（10⁹/L）×血小板（10⁹/L）公式计算。
HALP评分均值为46.81，改良HALP评分均值为2,758,401.21。582例（90.8%）患者成功完成了腹腔镜胆囊切除术（LC）。在检查HALP和改良HALP评分与手术类型之间的关系时，发现LC组与腹腔镜及开腹胆囊切除术（LTOC）组之间的HALP和改良HALP评分中位数分布存在统计学显著差异。对于HALP评分<34.43且改良HALP评分<2,077,019的患者，转为开腹手术的可能性增加，敏感性分别为65.5%对58.8%，特异性分别为66.1%对59.3%。在接受手术的患者中，HALP评分和改良HALP评分截断组之间的LTOC存在显著差异（<0.001和，=0.007）。
HALP评分评估是为AC患者设计合适治疗和管理策略的一种有前景且有价值的评估方法。
