Yavuz Rıdvan, Aras Orhan, Çiyiltepe Hüseyin, Dinçer Onur İlkay, Alparslan Ahmet Şükrü, Çakır Tebessüm
Gastroenterology Surgery Department, Antalya Training and Research Hospital, Varlık, Kazım Karabekir Cd., Muratpaşa 07100, Antalya, Turkey.
Radiology Department, Antalya Training and Research Hospital, Varlık, Kazım Karabekir Cd., Muratpaşa 07100, Antalya, Turkey.
Diagnostics (Basel). 2025 Jan 15;15(2):190. doi: 10.3390/diagnostics15020190.
: Microsatellite-stable (MSS) and microsatellite-instable (MSI) colon cancer (CC) cases have different characteristics. These characteristics may impact the accuracy of abdominal computed tomography (CT) scan examinations in MSI CC. : A retrospective analysis was conducted to examine the effects of MSI CC on patients' clinical and tumor characteristics. We determined the accuracy of radiological T and N staging compared to pathological T and N staging in CC patients and evaluated the influence of tumor- and patient-related factors on this accuracy. : A total of 131 CC patients who had undergone surgical resection were analyzed. Mismatch repair-deficient (dMMR) CC was predominantly found in the right hemicolon ( = 0.023); it was more likely to exhibit moderate (80.8%) or low-grade differentiation ( = 0.01) and had higher rates of mucinous differentiation ( = 0.001). The median neutrophil and platelet counts and C-reactive protein (CRP) levels at diagnosis were significantly higher in patients with dMMR CC ( = 0.022, = 0.022, and = 0.018). The depth of invasion influenced the CRP levels in dMMR CC cases ( = 0.015). The abdominal CT exam was accurate regarding the depth of colonic wall invasion in 58.1% and 38.5% of patients with mismatch repair-proficient (pMMR) and dMMR CC, respectively. The assessment of lymph node invasion was accurate in 44.8% of those with pMMR and 50.0% of those with dMMR CC. There was no significant difference in the accuracy in predicting the T and N statuses between the two groups. The accuracy in the determination of the T and N statuses was not affected by the parameters examined. : dMMR CC has specific characteristic features. MSI does not affect the accuracy of preoperative abdominal CT.
微卫星稳定（MSS）和微卫星不稳定（MSI）的结肠癌（CC）病例具有不同的特征。这些特征可能会影响MSI CC腹部计算机断层扫描（CT）检查的准确性。：进行了一项回顾性分析，以研究MSI CC对患者临床和肿瘤特征的影响。我们确定了CC患者中放射学T和N分期与病理T和N分期相比的准确性，并评估了肿瘤和患者相关因素对该准确性的影响。：总共分析了131例接受手术切除的CC患者。错配修复缺陷（dMMR）CC主要见于右半结肠（ = 0.023）；它更有可能表现为中度（80.8%）或低级别分化（ = 0.01），黏液分化率更高（ = 0.001）。dMMR CC患者诊断时的中性粒细胞和血小板计数中位数以及C反应蛋白（CRP）水平显著更高（ = 0.022、 = 0.022和 = 0.018）。浸润深度影响dMMR CC病例的CRP水平（ = 0.015）。腹部CT检查在错配修复功能正常（pMMR）和dMMR CC患者中，分别有58.1%和38.5%的患者对结肠壁浸润深度的判断准确。在pMMR患者中，44.8%的患者对淋巴结浸润的评估准确，在dMMR CC患者中这一比例为50.0%。两组在预测T和N状态的准确性方面没有显著差异。T和N状态的确定准确性不受所检查参数的影响。：dMMR CC具有特定的特征。MSI不影响术前腹部CT的准确性。
