Robert H. Lurie Comprehensive Cancer Center of Northwestern University.
UCSF Helen Diller Family Comprehensive Cancer Center.
J Natl Compr Canc Netw. 2024 Jun;22(2 D). doi: 10.6004/jnccn.2024.0029.
Colorectal cancer (CRC) is the fourth most frequently diagnosed cancer and the second leading cause of cancer death in the United States. Management of disseminated metastatic CRC involves various active drugs, either in combination or as single agents. The choice of therapy is based on consideration of the goals of therapy, the type and timing of prior therapy, the mutational profile of the tumor, and the differing toxicity profiles of the constituent drugs. This manuscript summarizes the data supporting the systemic therapy options recommended for metastatic CRC in the NCCN Guidelines for Colon Cancer.
结直肠癌（CRC）是美国第四大常见癌症，也是癌症死亡的第二大主要原因。转移性 CRC 的治疗包括各种联合或单药的有效药物。治疗方案的选择基于治疗目标、既往治疗的类型和时间、肿瘤的突变谱以及组成药物的不同毒性谱。本文总结了支持 NCCN 结肠癌指南中推荐的转移性 CRC 系统治疗选择的数据。
