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DNA甲基化和转录组分析揭示抗氧化途径和脂质代谢在皮肤颜色形成中的作用。

DNA Methylation and Transcriptome Profiling Reveal the Role of the Antioxidant Pathway and Lipid Metabolism in Skin Color Formation.

作者信息

Liu Yang, Wang Linna, Li Zhentong, Li Linlin, Ding Tangtang, Chen Shuai, Duan Pengfei, Wang Xinyi, Qiu Yishu, Ding Xiaoyu, Tian Yongsheng

机构信息

State Key Laboratory of Mariculture Biobreeding and Sustainable Goods, Yellow Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Qingdao 266071, China.

Key Laboratory for Sustainable Development of Marine Fisheries, Ministry of Agriculture and Rural Affairs, Yellow Sea Fisheries Research Institute, Qingdao 266071, China.

出版信息

Antioxidants (Basel). 2025 Jan 15;14(1):93. doi: 10.3390/antiox14010093.

DOI:10.3390/antiox14010093
PMID:39857428
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11763275/
Abstract

Leopard coral grouper (), possessing a distinct red body color, is an important species in commercial markets; however, the high ratio of black individuals under intensive cultivation has limited the commercial value of the species. To dissect the regulatory mechanisms underlying the red skin trait in , gene expression and DNA methylation modifications were compared between red and black skin tissues after astaxanthin treatment. Astaxanthin effectively increased the redness value a* and body weight. Multi-omics analyses revealed the crucial roles of pathways related to antioxidants and lipid metabolism, particularly "Tyrosine metabolism", "Melanogenesis", "Fatty acid metabolism", "Fatty acid elongation", and "Biosynthesis of unsaturated acids", in red skin coloration. A molecular network for the regulation of red skin coloration in was constructed, and , , , , , , , , , , , and were identified as key genes. Notably, , , and were negatively regulated by differential DNA methylation. Our results provide new insight into the molecular and epigenetic mechanisms of body color variation, representing a significant step towards breeding for the red skin trait in .

摘要

豹纹珊瑚鲈（），身体颜色呈独特的红色，是商业市场上的重要物种；然而，在集约化养殖中黑色个体比例较高，限制了该物种的商业价值。为了解析豹纹珊瑚鲈红色皮肤性状的调控机制，在虾青素处理后，对红色和黑色皮肤组织的基因表达和DNA甲基化修饰进行了比较。虾青素有效提高了红色值a*和体重。多组学分析揭示了与抗氧化剂和脂质代谢相关的途径，特别是“酪氨酸代谢”、“黑色素生成”、“脂肪酸代谢”、“脂肪酸延长”和“不饱和酸的生物合成”在红色皮肤着色中的关键作用。构建了豹纹珊瑚鲈红色皮肤着色调控的分子网络，并鉴定出、、、、、、、、、、和为关键基因。值得注意的是，、和受到DNA甲基化差异的负调控。我们的结果为体色变异的分子和表观遗传机制提供了新的见解，代表了在豹纹珊瑚鲈中培育红色皮肤性状的重要一步。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8226/11763275/3b4c95660844/antioxidants-14-00093-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8226/11763275/e9176affa104/antioxidants-14-00093-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8226/11763275/d18ab13761fd/antioxidants-14-00093-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8226/11763275/83d37b081ddf/antioxidants-14-00093-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8226/11763275/1f83b4923ad4/antioxidants-14-00093-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8226/11763275/884aa3e31f7c/antioxidants-14-00093-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8226/11763275/64a0b5c3374f/antioxidants-14-00093-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8226/11763275/b5d9537e862e/antioxidants-14-00093-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8226/11763275/3b4c95660844/antioxidants-14-00093-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8226/11763275/e9176affa104/antioxidants-14-00093-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8226/11763275/d18ab13761fd/antioxidants-14-00093-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8226/11763275/83d37b081ddf/antioxidants-14-00093-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8226/11763275/1f83b4923ad4/antioxidants-14-00093-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8226/11763275/884aa3e31f7c/antioxidants-14-00093-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8226/11763275/64a0b5c3374f/antioxidants-14-00093-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8226/11763275/b5d9537e862e/antioxidants-14-00093-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8226/11763275/3b4c95660844/antioxidants-14-00093-g008.jpg

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Deciphering scavenger receptors reveals key regulators in the intestine that function in carotenoid coloration of leopard coral groupers (Plectropomus leopardus).
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Int J Biol Macromol. 2024 Mar;260(Pt 2):129387. doi: 10.1016/j.ijbiomac.2024.129387. Epub 2024 Jan 20.
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