Ávila Marcela, Mora Sánchez Mariana G, Bernal Amador Alma Sofía, Paniagua Ramón
Unidad de Investigación Médica en Enfermedades Nefrológicas, Hospital de Especialidades, CMN SXXI, Instituto Mexicano del Seguro Social, Ciudad de México 06720, Mexico.
Biomolecules. 2025 Jan 1;15(1):41. doi: 10.3390/biom15010041.
Serum creatinine levels are the most used clinical marker to estimate renal function as the glomerular function rate because it is simple, fast, and inexpensive. However, creatinine has limitations, as its levels can be influenced by factors such as advanced age, physical activity, protein-rich diets, male gender, medications, and ethnicity. Serum cystatin C and its combination with serum creatinine may serve as an alternative since these factors do not affect it. Most creatinine synthesis occurs in the muscles, making it a valuable marker for assessing lean body mass within body composition. This measurement is crucial for evaluating and monitoring nutritional status in patients with chronic kidney disease. This review aimed to discuss the literature on creatinine metabolism, its advantages and disadvantages in assessing renal function, and its utility in measuring lean body mass. The variability in the creatinine generation rate among individuals should be considered when assessing the glomerular function rate.
血清肌酐水平是评估肾功能（作为肾小球滤过率）时最常用的临床指标，因为它简单、快速且成本低廉。然而，肌酐存在局限性，因为其水平会受到高龄、体力活动、高蛋白饮食、男性性别、药物和种族等因素的影响。血清胱抑素C及其与血清肌酐的联合检测可能是一种替代方法，因为这些因素不会对其产生影响。大多数肌酐在肌肉中合成，这使其成为评估身体组成中瘦体重的重要指标。该测量对于评估和监测慢性肾脏病患者的营养状况至关重要。本综述旨在讨论有关肌酐代谢的文献、其在评估肾功能方面的优缺点以及在测量瘦体重方面的用途。在评估肾小球滤过率时，应考虑个体间肌酐生成率的差异。
