• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

携带产乙酸素的纳米混悬液的特性及其对家禽业相关细菌的影响

Characterization of an Acetogenin-Carrying Nanosuspension and Its Effect on Bacteria of Interest in the Poultry Industry.

作者信息

López-Romero Brandon A, Aguilar-Hernández Gabriela, Hargis Billy M, García-Magaña María de Lourdes, López-García Ulises M, Ortiz-Basurto Rosa I, Zamudio-Ojeda Adalberto, Latorre Juan D, Montalvo-González Efigenia

机构信息

Laboratorio Integral de Investigación en Alimentos, Tecnológico Nacional de México, Instituto Tecnológico de Tepic, Tepic 63175, Mexico.

División de Ciencias Agropecuarias e Ingenierías, Centro Universitario de los Altos, Universidad de Guadalajara, Guadalajara 47600, Mexico.

出版信息

Microorganisms. 2024 Dec 25;13(1):18. doi: 10.3390/microorganisms13010018.

DOI:10.3390/microorganisms13010018
PMID:39858786
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11768020/
Abstract

This work aimed to develop a nanosuspension (NSps) as an acetogenin (ACGs) carrier, using soy lecithin (SL) and hydroxypropyl-β-cyclodextrin (βCD) named NSps-βCDSL-ACGs. It was characterized by various spectroscopic techniques (DLS, FTIR, UV-vis diffuse reflectance). Moreover, the NSps morphology was observed by transmission electron microscopy (TEM). Also, the antibacterial activity of NSps-βCDSL-ACGs was evaluated against strains of interest in the poultry sector. NSps-βCDSL-ACGs presented nanometric size (207-239 nm), acceptable polydispersity index (PDI) values (0.13-0.17) and a high Z potential value (-47.17-50.36 mV), demonstrating high stability. The presence of ACGs in NSps-βCDSL-ACGs was confirmed by FTIR analysis. The nanoparticles had a spherical shape and exhibited high inhibition potential against Enteritidis (88.18%), (88.01%), Typhimurium (86.28%) and Infantis (77.02%) strains up to 48 h, and a reduction of up to 3 log CFU/mL was achieved for Typhimurium. Therefore, NSps-βCDSL-ACGs is an attractive option for implementing ACGs administration in the poultry sector to reduce the use of antibiotics and minimize bacterial resistance.

摘要

本研究旨在开发一种纳米混悬液（NSps）作为产乙酸素（ACGs）的载体，使用大豆卵磷脂（SL）和羟丙基-β-环糊精（βCD），命名为NSps-βCDSL-ACGs。通过各种光谱技术（动态光散射、傅里叶变换红外光谱、紫外-可见漫反射）对其进行表征。此外，通过透射电子显微镜（TEM）观察NSps的形态。同时，评估了NSps-βCDSL-ACGs对家禽领域相关菌株的抗菌活性。NSps-βCDSL-ACGs呈现纳米级尺寸（207-239nm）、可接受的多分散指数（PDI）值（0.13-0.17）和高Z电位值（-47.17-50.36mV），表明具有高稳定性。通过傅里叶变换红外光谱分析证实了NSps-βCDSL-ACGs中存在ACGs。纳米颗粒呈球形，对肠炎沙门氏菌（88.18%）、（此处原文缺失一种细菌名称）（88.01%）、鼠伤寒沙门氏菌（86.28%）和婴儿沙门氏菌（77.02%）菌株在长达48小时内表现出高抑制潜力，对鼠伤寒沙门氏菌实现了高达3 log CFU/mL的减少。因此，NSps-βCDSL-ACGs是在家禽领域实施ACGs给药以减少抗生素使用和最小化细菌耐药性的一个有吸引力的选择。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d473/11768020/1a8f96bc0e37/microorganisms-13-00018-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d473/11768020/12e8a43ed97b/microorganisms-13-00018-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d473/11768020/82d8786f8448/microorganisms-13-00018-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d473/11768020/9eb0511ab48c/microorganisms-13-00018-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d473/11768020/1a8f96bc0e37/microorganisms-13-00018-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d473/11768020/12e8a43ed97b/microorganisms-13-00018-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d473/11768020/82d8786f8448/microorganisms-13-00018-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d473/11768020/9eb0511ab48c/microorganisms-13-00018-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d473/11768020/1a8f96bc0e37/microorganisms-13-00018-g004.jpg

相似文献

1
Characterization of an Acetogenin-Carrying Nanosuspension and Its Effect on Bacteria of Interest in the Poultry Industry.携带产乙酸素的纳米混悬液的特性及其对家禽业相关细菌的影响
Microorganisms. 2024 Dec 25;13(1):18. doi: 10.3390/microorganisms13010018.
2
Annonaceous acetogenins (ACGs) nanosuspensions based on a self-assembly stabilizer and the significantly improved anti-tumor efficacy.基于自组装稳定剂的番荔枝乙酰精宁（ACGs）纳米混悬液及其显著提高的抗肿瘤疗效。
Colloids Surf B Biointerfaces. 2016 Sep 1;145:319-327. doi: 10.1016/j.colsurfb.2016.05.012. Epub 2016 May 6.
3
Folate-targeting annonaceous acetogenins nanosuspensions: significantly enhanced antitumor efficacy in HeLa tumor-bearing mice.叶酸靶向藤黄烷酮纳米混悬液：显著提高荷 HeLa 肿瘤小鼠的抗肿瘤疗效。
Drug Deliv. 2018 Nov;25(1):880-887. doi: 10.1080/10717544.2018.1455761.
4
Folate-modified Annonaceous acetogenins nanosuspensions and their improved antitumor efficacy.叶酸修饰的番荔枝科乙酰精宁纳米混悬液及其增强的抗肿瘤功效。
Int J Nanomedicine. 2017 Jul 14;12:5053-5067. doi: 10.2147/IJN.S134284. eCollection 2017.
5
Annonaceous acetogenins nanosuspensions stabilized by PCL-PEG block polymer: significantly improved antitumor efficacy.由聚己内酯-聚乙二醇嵌段聚合物稳定的番荔枝科乙酰精宁纳米混悬液：显著提高抗肿瘤疗效。
Int J Nanomedicine. 2016 Jul 18;11:3239-53. doi: 10.2147/IJN.S108143. eCollection 2016.
6
A comparative study of PEO-PBO content on the targeting and anti-glioma activity of annonaceous acetogenins-loaded nanomicelles.载姜黄素纳米胶束中 PEO-PBO 含量对其靶向性和抗神经胶质瘤活性的比较研究。
Colloids Surf B Biointerfaces. 2024 Dec;244:114176. doi: 10.1016/j.colsurfb.2024.114176. Epub 2024 Aug 30.
7
Extraction of Acetogenins Using Thermosonication-Assisted Extraction from Seeds and Their Antifungal Activity.利用热声辅助提取法从种子中提取生物活性物质，并研究其抗真菌活性。
Molecules. 2022 Sep 16;27(18):6045. doi: 10.3390/molecules27186045.
8
Sensitive Tumor Cell Line for Annonaceous Acetogenins and High Therapeutic Efficacy at a Low Dose for Choriocarcinoma Therapy.用于冬凌草甲素的敏感肿瘤细胞系和低剂量绒毛膜癌治疗的高治疗效果。
J Biomed Nanotechnol. 2021 Oct 1;17(10):2062-2070. doi: 10.1166/jbn.2021.3175.
9
Enhanced anti-glioma activity of annonaceous acetogenins based on a novel liposomal co-delivery system with ginsenoside Rh2.基于新型脂质体共递送系统的人参皂苷 Rh2 增强姜科乙酰二萜的抗神经胶质瘤活性。
Drug Deliv. 2024 Dec;31(1):2324716. doi: 10.1080/10717544.2024.2324716. Epub 2024 Mar 31.
10
Comparative study of the protective effect against Salmonella colonisation in newly hatched SPF chickens using live, attenuated Salmonella vaccine strains, wild-type Salmonella strains or a competitive exclusion product.使用减毒活沙门氏菌疫苗株、野生型沙门氏菌菌株或竞争排斥产品对新孵化的无特定病原体（SPF）鸡抵御沙门氏菌定植的保护作用的比较研究。
Int J Food Microbiol. 1997 Apr 15;35(3):223-30. doi: 10.1016/s0168-1605(96)01236-6.

本文引用的文献

1
Annonaceae acetogenins: A potential treatment for gynecological and breast cancer.姜科原白头翁素类化合物：一种治疗妇科和乳腺癌的潜在方法。
Fitoterapia. 2024 Oct;178:106187. doi: 10.1016/j.fitote.2024.106187. Epub 2024 Aug 13.
2
Minoxidil Nanosuspension-Loaded Dissolved Microneedles for Hair Regrowth.米诺地尔纳米混悬剂负载的溶解型微针促进头发生长
AAPS PharmSciTech. 2024 Apr 5;25(4):75. doi: 10.1208/s12249-024-02771-4.
3
Global surveillance of antimicrobial resistance in food animals using priority drugs maps.利用重点药物分布图对食用动物中的抗菌药物耐药性进行全球监测。
Nat Commun. 2024 Jan 26;15(1):763. doi: 10.1038/s41467-024-45111-7.
4
Evaluation of Genotoxicity and Toxicity of L. Seeds and In Silico Studies.龙葵种子的遗传毒性和毒性评价及计算机模拟研究。
Molecules. 2022 Dec 27;28(1):231. doi: 10.3390/molecules28010231.
5
Extraction of Acetogenins Using Thermosonication-Assisted Extraction from Seeds and Their Antifungal Activity.利用热声辅助提取法从种子中提取生物活性物质，并研究其抗真菌活性。
Molecules. 2022 Sep 16;27(18):6045. doi: 10.3390/molecules27186045.
6
The Mechanism of Bacterial Resistance and Potential Bacteriostatic Strategies.细菌耐药机制及潜在抑菌策略
Antibiotics (Basel). 2022 Sep 8;11(9):1215. doi: 10.3390/antibiotics11091215.
7
Cationic liposomes co-deliver chemotherapeutics and siRNA for the treatment of breast cancer.阳离子脂质体共递送化疗药物和 siRNA 用于治疗乳腺癌。
Eur J Med Chem. 2022 Apr 5;233:114198. doi: 10.1016/j.ejmech.2022.114198. Epub 2022 Feb 17.
8
Antioxidant and antimicrobial activities of phytonutrients as antibiotic substitutes in poultry feed.植物营养素作为抗生素替代品在禽类饲料中的抗氧化和抗菌活性。
Environ Sci Pollut Res Int. 2022 Jan;29(4):5006-5031. doi: 10.1007/s11356-021-17401-w. Epub 2021 Nov 22.
9
Multisubstituted pyrimidines effectively inhibit bacterial growth and biofilm formation of Staphylococcus aureus.多取代嘧啶能有效抑制金黄色葡萄球菌的生长和生物膜形成。
Sci Rep. 2021 Apr 12;11(1):7931. doi: 10.1038/s41598-021-86852-5.
10
Dietary Origanum vulgare essential oil attenuates cypermethrin-induced biochemical changes, oxidative stress, histopathological alterations, apoptosis, and reduces DNA damage in Common carp (Cyprinus carpio).日粮牛至精油可减轻氯氰菊酯诱导的鲤鱼生化变化、氧化应激、组织病理学改变、细胞凋亡，并降低 DNA 损伤。
Aquat Toxicol. 2020 Nov;228:105624. doi: 10.1016/j.aquatox.2020.105624. Epub 2020 Sep 6.