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猪冠状动脉和心室心肌的肾上腺素能神经支配:正常状态及缺血后的荧光显微镜表现

Adrenergic innervation of coronary arteries and ventricular myocardium in the pig: fluorescence microscopic appearance in the normal state and after ischemia.

作者信息

Holmgren S, Abrahamsson T, Almgren O

出版信息

Basic Res Cardiol. 1985 Jan-Feb;80(1):18-26. doi: 10.1007/BF01906740.

DOI:10.1007/BF01906740
PMID:3985923
Abstract

A fluorescence histochemical study was performed to describe the adrenergic innervation of the coronary arteries and the left ventricular myocardium in the pig. Large bundles of adrenergic nerve fibres were almost exclusively found running along the large coronary arteries. The arteries usually show a dense innervation of the vessel wall, evenly distributed throughout the adventitia in the larger arteries and more concentrated to the adventitia-medial border in the smaller arteries and arterioles. Most parts of the left ventricular myocardium showed a dense adrenergic innervation, however, a moderate dense and in some areas even sparse innervation was observed towards the apex of the left ventricle. Following 10 or 20 min of ischemia a small reduction in fluorescence intensity was observed in 2 out of 6 hearts. In 4 of the hearts other changes of the appearance of the adrenergic terminals were found, e.g., an unsharp, spread-out or interrupted appearance.

摘要

进行了一项荧光组织化学研究,以描述猪冠状动脉和左心室心肌的肾上腺素能神经支配情况。大量肾上腺素能神经纤维束几乎仅沿着大冠状动脉走行。这些动脉通常显示血管壁有密集的神经支配,在较大动脉的外膜中均匀分布,而在较小动脉和小动脉中外膜-中膜边界处更为集中。左心室心肌的大部分区域显示有密集的肾上腺素能神经支配,然而,朝向左心室心尖处观察到中等密度甚至在某些区域稀疏的神经支配。缺血10或20分钟后,6颗心脏中有2颗观察到荧光强度略有降低。在4颗心脏中发现了肾上腺素能终末外观的其他变化,例如,模糊、分散或中断的外观。

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