Gianlorenço Anna Carolyna, Costa Valton, Fabris-Moraes Walter, Teixeira Paulo Eduardo Portes, Gonzalez Paola, Pacheco-Barrios Kevin, Ramos-Estebanez Ciro, Di Stadio Arianna, El-Hagrassy Mirret M, Camsari Deniz Durok, Wagner Tim, Dipietro Laura, Fregni Felipe
Neuromodulation Center and Center for Clinical Research Learning, Spaulding Rehabilitation Hospital, Massachusetts General Hospital, Harvard Medical School, 1575 Cambridge Street, Cambridge, MA 02115, USA.
Laboratory of Neuroscience and Neurological Rehabilitation, Physical Therapy Department, Federal University of Sao Carlos, Rodovia Washington Luis, km 235, Sao Carlos 13565-905, SP, Brazil.
Life (Basel). 2024 Dec 30;15(1):27. doi: 10.3390/life15010027.
This study aimed to explore the potential associations between voice metrics of patients with PD and their motor symptoms.
Motor and vocal data including the Unified Parkinson's Disease Rating Scale part III (UPDRS-III), Harmonic-Noise Ratio (HNR), jitter, shimmer, and smoothed cepstral peak prominence (CPPS) were analyzed through exploratory correlations followed by univariate linear regression analyses. We employed these four voice metrics as independent variables and the total and sub-scores of the UPDRS-III as dependent variables.
Thirteen subjects were included, 76% males and 24% females, with a mean age of 62.9 ± 10.1 years, and a median Hoehn and Yahr stage of 2.3 ± 0.7. The regression analysis showed that CPPS is associated with posture (UPDRS-III posture scores: β = -0.196; F = 10.0; = 0.01; R = 0.50) and UPDRS-III postural stability scores (β = -0.130; F = 5.57; = 0.04; R = 0.35). Additionally, the associations between CPPS and rapid alternating movement (β = -0.297; = 0.07), rigidity (β= -0.36; = 0.11), and body bradykinesia (β = -0.16; = 0.13) showed a trend towards significance.
These findings highlight the potential role of CPPS as a predictor of postural impairments secondary to PD, emphasizing the need for further investigation.
本研究旨在探讨帕金森病（PD）患者的嗓音指标与其运动症状之间的潜在关联。
通过探索性相关性分析，随后进行单变量线性回归分析，对包括统一帕金森病评定量表第三部分（UPDRS-III）、谐波噪声比（HNR）、抖动、闪烁和经平滑处理的谐波峰值突出度（CPPS）在内的运动和嗓音数据进行分析。我们将这四个嗓音指标作为自变量，将UPDRS-III的总分和各分项得分作为因变量。
纳入了13名受试者，其中男性占76%，女性占24%，平均年龄为62.9±10.1岁，Hoehn和Yahr分期的中位数为2.3±0.7。回归分析表明，CPPS与姿势（UPDRS-III姿势得分：β = -0.196；F = 10.0；P = 0.01；R = 0.50）和UPDRS-III姿势稳定性得分（β = -0.130；F = 5.57；P = 0.04；R = 0.35）相关。此外，CPPS与快速交替运动（β = -0.297；P = 0.07）、僵硬（β = -0.36；P = 0.11）和身体运动迟缓（β = -0.16；P = 0.13）之间的关联呈现出显著趋势。
这些发现凸显了CPPS作为PD继发姿势障碍预测指标的潜在作用，强调了进一步研究的必要性。
