Petroncini Matteo, Salvaterra Elena, Valentini Leonardo, Bonucchi Silvia, Daddi Niccolò, Pastore Saverio, Bertoglio Pietro, Solli Piergiorgio, Antonacci Filippo
Division of Thoracic Surgery, IRCCS Azienda Ospedaliero Universitaria Di Bologna, Via Albertoni 15, 40138 Bologna, Italy.
Division of Interventional Pulmonology, IRCCS Azienda Ospedaliero Universitaria Di Bologna, Via Albertoni 15, 40138 Bologna, Italy.
Life (Basel). 2024 Dec 31;15(1):37. doi: 10.3390/life15010037.
(1) Background: Ex Vivo Lung Perfusion (EVLP) is a technique designed to assess and recondition marginal lungs, potentially expanding the donor pool and improving transplant outcomes (2) Methods: This retrospective study evaluated lung transplantation outcomes after EVLP. Donor lungs were assessed using the Toronto protocol, with data on hemodynamics, gas exchange, and perfusion parameters collected and analyzed. Post-transplant complications and survival rates were also examined. (3) Results: Over five years, 17 EVLP procedures were performed. Despite an improvement in lung function, 47% of donor lungs were rejected after EVLP. EVLP-reconditioned lungs showed comparable survival rates to standard transplants, but complications like sepsis and primary graft dysfunction (PGD) occurred. (4) Conclusions: EVLP shows promise in expanding the donor organ availability and reducing PGD, but nearly half of the lungs assessed were rejected. Further research is necessary to optimize EVLP and address potential complications like lung injury and sepsis.
(1) 背景：体外肺灌注（EVLP）是一种旨在评估和修复边缘肺的技术，有可能扩大供体库并改善移植结果。(2) 方法：这项回顾性研究评估了EVLP后的肺移植结果。使用多伦多方案对供体肺进行评估，收集并分析血流动力学、气体交换和灌注参数数据。还检查了移植后并发症和生存率。(3) 结果：在五年期间，进行了17例EVLP手术。尽管肺功能有所改善，但47%的供体肺在EVLP后被拒绝。经EVLP修复的肺显示出与标准移植相当的生存率，但出现了败血症和原发性移植功能障碍（PGD）等并发症。(4) 结论：EVLP在扩大供体器官可用性和降低PGD方面显示出前景，但近一半评估的肺被拒绝。有必要进行进一步研究以优化EVLP并解决肺损伤和败血症等潜在并发症。
