Zouzoulas Dimitrios, Tsolakidis Dimitrios, Sofianou Iliana, Karalis Tilemachos, Aristotelidis Michalis, Tzitzis Panagiotis, Deligeoroglou Evangelia, Topalidou Maria, Timotheadou Eleni, Grimbizis Grigoris
1st Department of Obstetrics & Gynecology, Aristotle University of Thessaloniki, "Papageorgiou" Hospital, 564 29 Thessaloniki, Greece.
Radiotherapy Department, "Papageorgiou" Hospital, 564 29 Thessaloniki, Greece.
Life (Basel). 2025 Jan 17;15(1):122. doi: 10.3390/life15010122.
(1) Background: Suspicious adnexal masses should be referred to gynecological oncology units. However, when surgery waiting lists are prolonged, these patients usually suffer from a delay in surgery. This could have a negative impact on their prognosis when the final diagnosis is ovarian cancer (OC). The primary aim of this study was to investigate the impact of surgery delay on the oncological results of early-stage ovarian cancer patients. (2) Methods: We retrospectively reviewed the records of early-stage OC patients who underwent surgery in the 1st Department of Obstetrics and Gynecology from 2012 to 2019. Time to surgery was defined as the time interval from the day of first examination to the day of surgery. (3) Results: A total of 72 patients were categorized into two groups, with a cut-off point of 5 weeks: 32 were treated ≤ 5 weeks (group A), and 40 > 5 weeks (group B). Concerning age, BMI or comorbidities, no differences were found between the two groups. Furthermore, no differences were presented in the post-operative complications rate, hospital stay, ICU admittance, or in disease-free ( = 0.48) and overall survival rates ( = 0.703). (4) Conclusions: Suspicious adnexal masses should undergo careful differential diagnosis to avoid delays in the "wait and see" period when the final diagnosis is positive for malignancy. However, the time to surgery for early-stage OC over 5 weeks seems to be relatively safe, with no impact on the mortality, morbidity, or recurrence rate.
(1) 背景：可疑附件包块应转诊至妇科肿瘤科室。然而，当手术等待名单延长时，这些患者通常会经历手术延迟。当最终诊断为卵巢癌（OC）时，这可能会对其预后产生负面影响。本研究的主要目的是调查手术延迟对早期卵巢癌患者肿瘤学结果的影响。(2) 方法：我们回顾性分析了2012年至2019年在第一妇产科接受手术的早期OC患者的记录。手术时间定义为从首次检查之日到手术之日的时间间隔。(3) 结果：总共72例患者分为两组，以5周为分界点：32例在≤5周内接受治疗（A组），40例>5周（B组）。在年龄、体重指数或合并症方面，两组之间未发现差异。此外，术后并发症发生率、住院时间、重症监护病房入住率、无病生存率（=0.48）和总生存率（=0.703）也没有差异。(4) 结论：对于可疑附件包块，应进行仔细的鉴别诊断，以避免在“观察等待”期出现延迟，尤其是当最终诊断为恶性肿瘤时。然而，早期OC患者手术时间超过5周似乎相对安全，对死亡率、发病率或复发率没有影响。
