Cui Peipei, Yang Yan
College of Architecture and Arts, Taiyuan University of Technology, Jinzhong 030060, China.
College of Chemistry and Chemical Engineering, Taiyuan University of Technology, Taiyuan 030024, China.
Molecules. 2025 Jan 16;30(2):340. doi: 10.3390/molecules30020340.
A series of novel triazone derivatives containing aldehyde hydrazone or ketone hydrazone moieties were designed, synthesized and their biological activities were investigated against , , , , and 14 Kinds of fungi. Most of the aldehyde hydrazone exhibited excellent insecticidal activities against . In particular, the aphicidal activities of compounds (35%) and (30%) were equivalent to pymetrozine (30%) at 5 mg/kg. The aphicidal activities of derivatives , , , , , , and against were higher than that of pymetrozine. Compound (100%) exhibited good larvicidal activities against at 0.25 mg/kg. Most derivatives exhibited broad-spectrum fungicidal activities against 14 kinds of plant fungi at 50 mg/kg. Thirty-nine compounds exhibited a more than 50% inhibition rate against . Compounds , and were expected to be the leading structure for the development of new triazone insecticides agents.
设计并合成了一系列含有醛腙或酮腙部分的新型三唑酮衍生物，并研究了它们对[具体害虫名称缺失]、[具体害虫名称缺失]、[具体害虫名称缺失]、[具体害虫名称缺失]、[具体害虫名称缺失]和14种真菌的生物活性。大多数醛腙对[具体害虫名称缺失]表现出优异的杀虫活性。特别是，化合物[具体化合物编号缺失]（35%）和[具体化合物编号缺失]（30%）在5mg/kg时的杀蚜活性与吡蚜酮（30%）相当。衍生物[具体衍生物编号缺失]、[具体衍生物编号缺失]、[具体衍生物编号缺失]、[具体衍生物编号缺失]、[具体衍生物编号缺失]、[具体衍生物编号缺失]、[具体衍生物编号缺失]和[具体衍生物编号缺失]对[具体害虫名称缺失]的杀蚜活性高于吡蚜酮。化合物[具体化合物编号缺失]（100%）在0.25mg/kg时对[具体害虫名称缺失]表现出良好的杀幼虫活性。大多数衍生物在50mg/kg时对14种植物真菌表现出广谱杀菌活性。39种化合物对[具体真菌名称缺失]的抑制率超过50%。化合物[具体化合物编号缺失]、[具体化合物编号缺失]和[具体化合物编号缺失]有望成为开发新型三唑酮杀虫剂的先导结构。
