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阈下微脉冲激光治疗慢性中心性浆液性脉络膜视网膜病变后的脉络膜重塑:短期结果

Choroidal Remodeling After Subthreshold Micropulse Laser in Chronic Central Serous Chorioretinopathy: Short-Term Outcomes.

作者信息

Viggiano Pasquale, Scotti Giacomo, Termite Alba Chiara, Savastano Alfonso, Boscia Giacomo, Clemente Arcangelo, Salvelli Antonio, Giancipoli Ermete, Pignatelli Francesco, Evangelista Federica, Alessio Giovanni, Boscia Francesco

机构信息

Department of Translational Biomedicine Neuroscience, University of Bari "Aldo Moro", 70121 Bari, Italy.

Department of Ophthalmology, Ente Ecclesiastico Ospedale Generale Regionale "F. Miulli", 70021 Acquaviva delle Fonti, Italy.

出版信息

J Clin Med. 2025 Jan 7;14(2):306. doi: 10.3390/jcm14020306.

Abstract

: To evaluate the effects of subthreshold micropulse laser treatment (SMLT) on choroidal architecture in chronic central serous chorioretinopathy (CSC) and their correlations with functional outcomes. : This retrospective study included 48 eyes with chronic CSC that were treated with 577 nm SMLT. The choroidal thickness (CT); Sattler's layer and choriocapillaris complex thickness (SLCCT); Haller's layer thickness (HLT); subretinal fluid (SRF); and best-corrected visual acuity (BCVA) were assessed at baseline and at 2 months post treatment. : At 2 months, the SLCCT increased from 185.92 ± 80.89 μm to 214.17 ± 83.36 μm ( = 0.023), and the total CT increased from 444.46 ± 80.43 μm to 484.33 ± 93.19 μm ( = 0.002). The SRF height decreased from 140.38 ± 95.89 μm to 57.58 ± 63.54 μm ( < 0.001), with complete resolution in 79.2% of cases. The BCVA improved from 0.41 ± 0.48 to 0.22 ± 0.30 logMAR ( < 0.001). Changes in the SLCCT correlated negatively with BCVA changes (r = -0.48, = 0.025) and positively with total CT changes (r = 0.687, < 0.001). : SMLT induces significant choroidal remodeling in chronic CSC, particularly affecting the Sattler-Bruch layer complex. The increase in the SLCCT correlates with visual improvement, challenging the conventional understanding of choroidal thinning in CSC treatment.

摘要

评估阈下微脉冲激光治疗(SMLT)对慢性中心性浆液性脉络膜视网膜病变(CSC)脉络膜结构的影响及其与功能转归的相关性。:这项回顾性研究纳入了48例接受577 nm SMLT治疗的慢性CSC患眼。在基线和治疗后2个月评估脉络膜厚度(CT)、萨特勒层和脉络膜毛细血管复合体厚度(SLCCT)、哈勒层厚度(HLT)、视网膜下液(SRF)和最佳矫正视力(BCVA)。:2个月时,SLCCT从185.92±80.89μm增加至214.17±83.36μm(P = 0.023),总CT从444.46±80.43μm增加至484.33±93.19μm(P = 0.002)。SRF高度从140.38±95.89μm降至57.58±63.54μm(P < 0.001),79.2%的病例完全消退。BCVA从0.41±0.48提高至0.22±0.30 logMAR(P < 0.001)。SLCCT的变化与BCVA变化呈负相关(r = -0.48,P = 0.025),与总CT变化呈正相关(r = 0.687,P < 0.001)。:SMLT可在慢性CSC中诱导显著的脉络膜重塑,尤其影响萨特勒-布鲁赫层复合体。SLCCT的增加与视力改善相关,这对CSC治疗中脉络膜变薄的传统认识提出了挑战。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/be50/11765888/21b76c6757a0/jcm-14-00306-g001.jpg

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