Ophthalmology Clinic, Department of Medicine and Science of Ageing, "G. d'Annunzio" University Chieti-Pescara, 66100 Chieti, Italy.
Laboratory of Biostatistics, Department of Medical, Oral and Biotechnological Sciences, "G. d'Annunzio" University Chieti-Pescara, 66100 Chieti, Italy.
Medicina (Kaunas). 2024 Oct 12;60(10):1674. doi: 10.3390/medicina60101674.
: The aim of the present study is to analyze choroidal and choriocapillaris structural and functional changes in eyes affected by Central serous chorioretinopathy after Photodynamic Therapy (PDT) and Subthreshold Micropulse laser (SML) treatment. : Forty-two eyes of forty-two patients were analyzed in this observational study. Twenty-four patients underwent SML treatment, whereas eighteen patients were treated with PDT. Examinations were performed at baseline and after 3 months of treatment. Main outcome measures were: Best corrected visual acuity (BCVA), central macular thickness (CMT), central choroidal thickness (CCT), pigment epithelial detachment (PED) presence and maximum height (PEDMH), and choroidal vascularity index (CVI) measured by means of Spectralis HRA + OCT (Heidelberg Engineering, Heidelberg, Germany) Optical coherence tomography (OCT) and choriocapillaris flow voids (CCFV) measured on Optical Coherence Tomography Angiography (OCT-A) platform PLEX Elite 9000 device (Carl Zeiss Meditec Inc., Dublin, CA, USA). : Changes in BCVA were registered in both groups over time ( < 0.001). Structural changes in terms of reduced CMT and PED presence were noted in the two groups at follow-up ( < 0.001 and = 0.001, respectively). Structural and functional choroidal changes were found in the two groups with reduced CCT and CVI over time ( = 0.004 and = 0.007, respectively), with significant differences between the two groups for CVI parameter ( = 0.001). CCFV increased over time in the PDT group and decreased in the SML group. : PDT and SML are effective approaches in CSC eyes and are able to improve structural and functional parameters over time. Choroidal and choriocapillaris parameters are promising biomarkers able to monitor disease course, showing greater impact of PDT on choroid-choriocapillaris complex over time.
: 本研究旨在分析 PDT 和 SML 治疗后 CSCR 患者脉络膜和脉络膜毛细血管的结构和功能变化。 : 本观察性研究共分析了 42 例 42 只眼的患者。24 例患者行 SML 治疗，18 例患者行 PDT 治疗。基线和治疗后 3 个月进行检查。主要观察指标：最佳矫正视力（BCVA）、中心黄斑厚度（CMT）、中心脉络膜厚度（CCT）、色素上皮脱离（PED）的存在和最大高度（PEDMH）以及通过 Spectralis HRA + OCT（Heidelberg Engineering，Heidelberg，Germany）光学相干断层扫描（OCT）和脉络膜血管指数（CVI）测量、通过光学相干断层扫描血管造影（OCT-A）平台 PLEX Elite 9000 设备（Carl Zeiss Meditec Inc.，Dublin，CA，USA）测量的脉络膜毛细血管血流缺失（CCFV）。 : 两组患者的 BCVA 随时间发生变化（ < 0.001）。两组患者在随访时均发现 CMT 降低和 PED 存在减少（分别为 < 0.001 和 = 0.001）。两组患者的结构和功能变化均表现为 CCT 和 CVI 随时间降低（分别为 = 0.004 和 = 0.007），两组间 CVI 参数差异有统计学意义（ = 0.001）。PDT 组脉络膜毛细血管血流缺失随时间增加，SML 组减少。 : PDT 和 SML 是治疗 CSCR 的有效方法，可随时间改善结构和功能参数。脉络膜和脉络膜毛细血管参数是有前途的生物标志物，可监测疾病进程，随时间推移 PDT 对脉络膜-脉络膜毛细血管复合体的影响更大。
