Barbera Giorgio, Ottaviano Caterina, Lobbia Guido, Rizzo Tommaso, Zatta Esmeralda, Nocini Riccardo
Head and Neck Department, Azienda Ospedaliera Universitaria Integrata di Verona, Piazzale Aristide Stefani, 1, 37126 Verona, Italy.
Head and Neck Department, University of Verona, Piazzale Ludovico Antonio Scuro 10, 37134 Verona, Italy.
J Clin Med. 2025 Jan 10;14(2):415. doi: 10.3390/jcm14020415.
Frey's syndrome surgical treatment may be either prophylactic or therapeutic. The aim of this study is to summarize the state of the art in Frey's syndrome surgical treatment after parotidectomy and review indications, advantages, and disadvantages of different surgical options. The study was conducted following the PRISMA guidelines for scoping reviews; to fulfill the research enquiries, four different electronic databases (PubMed, Scopus, Cochrane, and Web of Science) were searched using the PICO protocol and key words in Frey's syndrome surgical treatment. A total of 15 articles met the inclusion criteria. Multiple surgical strategies have been developed over the last fifty years in an attempt to treat gustatory sweating; nevertheless, the surgical results are not always as effective as desired, and a gold standard has not been developed yet. Within the limitations of the study, a shift in surgical approaches over the years has been noted: tympanic neurectomy was the most frequently employed technique until the 1980s; more recently, local flaps interposed between the parotid tissue and skin layer have been the treatment of choice. : Surgery is a viable option in Frey's syndrome treatment, and it is indicated in cases of medical treatment inefficacy, tumor recurrence, invalidating symptoms, and unaesthetic surgical sequelae.
Frey综合征的外科治疗可以是预防性的或治疗性的。本研究的目的是总结腮腺切除术后Frey综合征外科治疗的现状，并回顾不同手术选择的适应证、优点和缺点。本研究遵循PRISMA范围综述指南进行；为满足研究需求，使用PICO方案和Frey综合征外科治疗的关键词检索了四个不同的电子数据库（PubMed、Scopus、Cochrane和Web of Science）。共有15篇文章符合纳入标准。在过去五十年里，人们开发了多种手术策略来治疗味觉性出汗；然而，手术结果并不总是如预期那样有效，而且尚未形成金标准。在本研究的局限性范围内，已注意到多年来手术方法的转变：直到20世纪80年代，鼓室神经切除术是最常用的技术；最近，置于腮腺组织和皮肤层之间的局部皮瓣已成为首选治疗方法。手术是Frey综合征治疗的一种可行选择，适用于药物治疗无效、肿瘤复发、症状严重影响生活及手术后遗症不美观的情况。
