Abat Ferran, Torras Jordi, Garcia Alba, Jordán Enrique, Roby Matías, Yáñez Roberto, De la Fuente Carlos
GRACIS Research Group (GRC 01604), Sports Orthopaedic Department, ReSport Clinic, Higher School of Health Sciences Tecnocampus, Pompeu Fabra University, 08029 Barcelona, Spain.
Physiotherapy Department, ReSport Clinic, Blanquerna School of Health Science, Universitat Ramon Llull, 08022 Barcelona, Spain.
J Clin Med. 2025 Jan 16;14(2):544. doi: 10.3390/jcm14020544.
To determine whether 448 kHz capacitive-resistive monopolar radiofrequency (CRMR) after platelet-rich-plasma (PRP) injections can further reduce pain sensation within the first 72 h in an active population with patellar chondropathy. One-hundred fifty-three active patients with patellar chondropathy grade II-III were followed for three days after PRP injections with and without CRMR under a control-placebo study. They were clinically evaluated for pain sensation using a visual analog scale ranging from zero (no pain sensation) to ten (highest pain sensation). Pain sensation was described using medians and analyzed through the Friedman and Conover test for within-group comparison (pre-intervention, and 24, 48, and 72 h post-intervention) and the Mann-Whitney test for between-group comparisons (Intervention vs. Placebo) with α = 5% and 1-β = 80%. The placebo group showed statistical significance between pre-intervention and 24 h (Δ = -2.0 pts, < 0.001), baseline and 48 h (Δ = -2.0 pts, < 0.001), baseline and 72 h (Δ = -3.0 pts, < 0.001), 24 h and 48 h (Δ = 0.0 pts, < 0.016), and 24 h and 72 h (Δ = -1.0 pts, < 0.001). The radiofrequency group showed statistical significance between baseline and 24 h (Δ = -7.0 pts, < 0.001), baseline and 48 h (Δ = -7.0 pts, < 0.001), baseline and 72 h (Δ = -8.0 pts, < 0.001), 24 h and 72 h (Δ = -1.0 pts, < 0.001), and 48 h and 72 h (Δ = -1.0 pts, < 0.001). The placebo and radiofrequency groups were significantly different at 24 h (Δ = 4.0 pts, < 0.001), 48 h (Δ = 4.0 pts, < 0.001), and 72 h (Δ = 4.0 pts, < 0.001). CRMR therapy administered after knee intra-articular injections of PRP within the first 72 h in active populations with patellar chondropathy reduces pain sensation with a median difference of 8.0 pts compared to baseline and 4.0 pts compared to placebo group.
为了确定在富含血小板血浆（PRP）注射后进行448kHz电容电阻单极射频（CRMR）治疗，是否能在患有髌软骨病的活跃人群中，在最初72小时内进一步减轻疼痛。在一项对照安慰剂研究中，153名II - III级髌软骨病活跃患者在接受PRP注射后，分别接受和不接受CRMR治疗，并随访三天。使用视觉模拟量表对他们的疼痛进行临床评估，量表范围从0（无疼痛感）到10（最高疼痛感）。用中位数描述疼痛感觉，并通过Friedman检验和Conover检验进行组内比较（干预前、干预后24、48和72小时），以及通过Mann - Whitney检验进行组间比较（干预组与安慰剂组），α = 5%，1 - β = 80%。安慰剂组在干预前与24小时之间（Δ = -2.0分，< 0.001）、基线与48小时之间（Δ = -2.0分，< 0.001）、基线与72小时之间（Δ = -3.0分，< 0.001）、24小时与48小时之间（Δ = 0.0分，< 0.016）以及24小时与72小时之间（Δ = -1.0分，< 0.001）显示出统计学意义。射频组在基线与24小时之间（Δ = -7.0分，< 0.001）、基线与48小时之间（Δ = -7.0分，< 0.001）、基线与72小时之间（Δ = -8.0分，< 0.００１）、24小时与72小时之间（Δ = -1.0分，< 0.001）以及48小时与72小时之间（Δ = -1.0分，< 0.001）显示出统计学意义。安慰剂组和射频组在24小时（Δ = 4.0分，< 0.001）、48小时（Δ = 4.0分，< 0.001）和72小时（Δ = 4.0分，< 0.001）存在显著差异。在患有髌软骨病的活跃人群中，在膝关节内注射PRP后的最初72小时内进行CRMR治疗，与基线相比疼痛感觉减轻，中位数差异为8.0分，与安慰剂组相比为4.0分。
